Date of download: 10/14/2017 Copyright © ASME. All rights reserved. From: Photoacoustic Detection of Melanoma Micrometastasis in Sentinel Lymph Nodes J Biomech Eng. 2009;131(7):074519-074519-5. doi:10.1115/1.3169247 Figure Legend: A histological section of a human lymph node stained with hematoxylin and eosin. (left) The intersecting double arrows span the area, which is infiltrated with melanoma cells. This area is located at the periphery of this lymph node. (right) The indicated area is infiltrated heavily by melanoma cells, which are large cells with abundant cytoplasm. The arrow indicates a single melanoma cell.

Date of download: 10/14/2017 Copyright © ASME. All rights reserved. From: Photoacoustic Detection of Melanoma Micrometastasis in Sentinel Lymph Nodes J Biomech Eng. 2009;131(7):074519-074519-5. doi:10.1115/1.3169247 Figure Legend: The photoacoustic setup for detecting micrometastasis in intact lymph nodes. The position of only one of three acoustic transducers is shown here.

Date of download: 10/14/2017 Copyright © ASME. All rights reserved. From: Photoacoustic Detection of Melanoma Micrometastasis in Sentinel Lymph Nodes J Biomech Eng. 2009;131(7):074519-074519-5. doi:10.1115/1.3169247 Figure Legend: (left) Photoacoustic response from lymph nodes without melanoma for all three detectors show no signal with a noise floor of approximately 100 μV. (right) For the lymph nodes with melanoma, each sensor shows a distinct photoacoustic wave, with detector 1 showing one at 9.5 μs, detector 2 showing one at 5 μs, and detector 3 showing one at 4 μs.

Date of download: 10/14/2017 Copyright © ASME. All rights reserved. From: Photoacoustic Detection of Melanoma Micrometastasis in Sentinel Lymph Nodes J Biomech Eng. 2009;131(7):074519-074519-5. doi:10.1115/1.3169247 Figure Legend: The average signals from irradiating pig lymph nodes are shown here. The error bars denote standard deviation of the measurements. The amplitudes are shown in millivolts and correspond approximately by 100 mV per bar of pressure.