Tissue Repair Clot Clean up Scab Restored blood supply Granulation

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Presentation transcript:

Tissue Repair Clot Clean up Scab Restored blood supply Granulation Regeneration and fibrosis Fibrous tissue matures Figure 4.12a

Barrier penetration / Tissue Trauma Causes inflammation, characterized by: Vasodilation Dilation of blood vessels Increase in vessel permeability Redness, heat, swelling (edema), and pain

Tissue repair - The inflammatory response Histamine is released from mast cells in the C.T. And causes vasodilation. Location of mast cells

Chemokines cause leukocyte extravasation

Leukocyte jobs 1. Neutrophils - 2. Macrophages - 3. Dead cells and fluid leaked from the capillaries may accumulate as pus in the area before it is absorbed by the body

Tissue repair - Granulation Fibroblasts Capillaries Collagen Figure 4.12b

Tissue Repair-Regeneration regenerated e.t. with underlying scar tissue Figure 4.12c