Whole brain white matter changes revealed by multiple diffusion metrics in multiple sclerosis: A TBSS study Yaou Liu, Yunyun Duan, Yong He, Chunshui.

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Whole brain white matter changes revealed by multiple diffusion metrics in multiple sclerosis: A TBSS study Yaou Liu, Yunyun Duan, Yong He, Chunshui Yu, Jun Wang, Jing Huang, Jing Ye, Paul M. Parizel, Kuncheng Li, Ni Shu European Journal of Radiology Volume 81, Issue 10, Pages 2826-2832 (October 2012) DOI: 10.1016/j.ejrad.2011.11.022 Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 TBSS results of FA, MD, AD and RD images between controls and MS patients. Green represents mean FA skeleton of all participants; red represents regions with decreased FA (1st row), increased MD (2nd row), increased AD (3rd row) and increased RD (4th row) in MS patients (P<0.05, FWE corrected for multiple comparisons); blue represents mean lesion probability distribution thresholded at 10%. European Journal of Radiology 2012 81, 2826-2832DOI: (10.1016/j.ejrad.2011.11.022) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Axial representations of overlapping white matter areas for decreased FA with increased RD and increased AD (top) and for increased MD with increased RD and increased AD (bottom) in MS patients. It depicts different change patterns of diffusion metrics in white matter skeletons in MS. European Journal of Radiology 2012 81, 2826-2832DOI: (10.1016/j.ejrad.2011.11.022) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 TBSS results from linear regression analysis showing voxels (in red-yellow, thickened for better visibility) where an increase in EDSS scores was significantly correlated with FA decrease, MD, AD and RD increase (from top to bottom) at P<0.05 (FWE corrected for multiple comparisons). Green represents the mean WM skeleton of all the participants. European Journal of Radiology 2012 81, 2826-2832DOI: (10.1016/j.ejrad.2011.11.022) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 TBSS results from linear regression analysis showing voxels (in red-yellow, thickened for better visibility) where an increase in disease durations was significantly correlated with FA decrease, MD, AD and RD increase (from top to bottom) at P<0.05 (FWE corrected for multiple comparisons). Green represents the mean WM skeleton of all the participants. European Journal of Radiology 2012 81, 2826-2832DOI: (10.1016/j.ejrad.2011.11.022) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 5 TBSS results from linear regression analysis showing voxels (in red-yellow, thickened for better visibility) where an increase in whole brain T2 lesion load was significantly correlated with FA decrease, MD, AD and RD increase (from top to bottom) at P<0.05 (FWE corrected for multiple comparisons). Green represents the mean WM skeleton of all the participants. European Journal of Radiology 2012 81, 2826-2832DOI: (10.1016/j.ejrad.2011.11.022) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions