Therapeutics 3: Antibiotics Tutoring By Alaina Darby

General Principles Morton’s Section

Which of the following antibiotics would be most likely to target g(-) bacteria? Small, nonpolar, lipophilic Large, nonpolar, lipophilic Small, polar, hydrophilic Large, polar, hydrophilic a

Jh has colitis. Which of the following is the most likely cause? S. aureus S. pneumoniae E. coli B. fragillis c

Which of the following would be least helpful for determining the causative bacteria? Culture of blood Culture of sputum Culture of CSF Culture of biopsied tissue b

Which of the following would most likely be considered bactericidal? Kills 98% of bacteria within 12 hours Kills 98% of bacteria within 24 hours Kills 99.9% of bacteria within 36 hours Kills 99.9% of bacteria within 48 hours a

Which of the following is a qualitative way to measure susceptibility? Broth dilution Kirby-Baur test Microtubule E-test b

For which of the following are concentrations regularly taken? Penicillin Azithromycin Zosyn Vancomycin d

Which of the following would most likely be susceptible? MIC 8, KB 5 MIC 8, KB 20 MIC 2, KB 5 MIC 2, KB 20 d

If the MIC of the organism is 3, which of the following antibiotics would work best? Peak of 2 Peak of 4 Peak of 6 Need more info d

If the MIC of the organism is 3, which of the following antibiotics would work best? Peak of 4, time above MIC is 9 hours, concentration dependent Peak of 6, time above MIC is 9 hours, concentration dependent Peak of 8, time above MIC is 5 hours, time dependent Need more info d

Ceftazidime is typically dosed 1g iv q8h Ceftazidime is typically dosed 1g iv q8h. If susceptibility comes back as “s-dd” how might it be dosed to be effective? 0.5g IV Q4H 1g IV Q4H 1g IV Q8H 2g IV Q8H d

Given the following, determine how you would treat the patient. Drug MIC SUSC Tetracycline >4 R TMP/SMX <10 S Vancomycin <1 Oxacillin 2 I IV Tetracycline at a high dose IV TMP/SMX at a normal dose + AMG IV Vancomycin at a high dose IV Nafcillin at a normal dose + AMG d

Which of the following is a static drug that works at the ribosome? TMP/SMX Gentamicin Erythromycin Rifampin c

JK has a MRSA infection. Why should he not be treated with dicloxacillin? He needs an IV option Resistance to dicoxacillin He needs a cidal agent He needs G(-) coverage b

JK has a MRSA infection. Why should he not be treated with dicloxacillin? Altered porin channel Efflux pump Absolute change in target Beta lactamase production c

RA (5 yo) has a respiratory infection that he picked up in daycare RA (5 yo) has a respiratory infection that he picked up in daycare. Which should he be given? Penicillin Amoxicillin Augmentin Zosyn c

RA (5 yo) is a st. jude patient that has a respiratory infection RA (5 yo) is a st. jude patient that has a respiratory infection. Which should he be given? Penicillin Amoxicillin Augmentin Zosyn d

RJ is to be given a CIVI of an antibiotic RJ is to be given a CIVI of an antibiotic. Which of the following is most likely? Zosyn Gentamicin Levofloxacin Azithromycin a

Which of the following is a case in which you might give a static and cidal agent together? TB CAP GNR HIV b

TJ has recently had surgery to transplant a lung due to lung cancer TJ has recently had surgery to transplant a lung due to lung cancer. He is a past smoker. During the surgery, he was intubated. He was also given anti-rejection drugs before and after the transplant. Which compromised his cellular immune function? Surgery Intubation Immunosuppressive drugs Smoking a

Which of the following would be considered SIRS? Oral temp 39 C, HR 85, WBC 10,000 Oral temp 37 C, HR 95, WBC 10,000 Oral temp 39 C, HR 85, WBC 2,000 Oral temp 37 C, HR 85, WBC 2,000 c

Which of the following would require the longest course of treatment? Endocarditis S. epidermitis bacteremia E. coli bacteremia Surgical prophylaxis a