American Journal of Ophthalmology

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Presentation transcript:

American Journal of Ophthalmology Bimatoprost Sustained-Release Implants for Glaucoma Therapy: 6-Month Results From a Phase I/II Clinical Trial Richard A. Lewis, William C. Christie, Douglas G. Day, E. Randy Craven, Thomas Walters, Marina Bejanian, Susan S. Lee, Margot L. Goodkin, Jane Zhang, Scott M. Whitcup, Michael R. Robinson Tin Aung, Allen D. Beck, William C. Christie, Michael Coote, Charles J. Crane, E. Randy Craven, Andrew Crichton, Douglas G. Day, F. Jane Durcan, William J. Flynn, Sébastien Gagné, Damien F. Goldberg, Delan Jinapriya, C. Starck Johnson, Shimon Kurtz, Richard A. Lewis, Steven L. Mansberger, Shamira A. Perera, Michael H. Rotberg, Robert M. Saltzmann, Howard I. Schenker, Michael E. Tepedino, Maria Imelda R. Yap-Veloso, Harvey S. Uy, Thomas R. Walters Richard A. Lewis, William C. Christie, Douglas G. Day, E. Randy Craven, Thomas Walters, Marina Bejanian, Susan S. Lee, Margot L. Goodkin, Jane Zhang, Scott M. Whitcup, Michael R. Robinson Tin Aung, Allen D. Beck, William C. Christie, Michael Coote, Charles J. Crane, E. Randy Craven, Andrew Crichton, Douglas G. Day, F. Jane Durcan, William J. Flynn, Sébastien Gagné, Damien F. Goldberg, Delan Jinapriya, C. Starck Johnson, Shimon Kurtz, Richard A. Lewis, Steven L. Mansberger, Shamira A. Perera, Michael H. Rotberg, Robert M. Saltzmann, Howard I. Schenker, Michael E. Tepedino, Maria Imelda R. Yap-Veloso, Harvey S. Uy, Thomas R. Walters American Journal of Ophthalmology Volume 175, Pages 137-147 (March 2017) DOI: 10.1016/j.ajo.2016.11.020 Copyright © 2016 The Author(s) Terms and Conditions

Figure 1 Study design. Bimatoprost SR = bimatoprost sustained-release implant; IOP = intraocular pressure. American Journal of Ophthalmology 2017 175, 137-147DOI: (10.1016/j.ajo.2016.11.020) Copyright © 2016 The Author(s) Terms and Conditions

Figure 2 Bimatoprost sustained-release implant applicator system. American Journal of Ophthalmology 2017 175, 137-147DOI: (10.1016/j.ajo.2016.11.020) Copyright © 2016 The Author(s) Terms and Conditions

Figure 3 Gonioscopic photographs of bimatoprost sustained-release implant 10 μg in the anterior chamber of an eye of a representative patient diagnosed with open-angle glaucoma at (Left) 2 weeks, (Center) 9 months, and (Right) 12 months after injection. American Journal of Ophthalmology 2017 175, 137-147DOI: (10.1016/j.ajo.2016.11.020) Copyright © 2016 The Author(s) Terms and Conditions

Figure 4 Mean change from baseline intraocular pressure (IOP; 8 AM time point) in study eyes after bimatoprost sustained-release implant administration and in fellow eyes treated with once-daily topical bimatoprost 0.03%. The percentage of study eyes that had not received rescue topical IOP-lowering medication or implant retreatment and remained in the analysis is indicated, as is the percentage of fellow eyes that had not received rescue topical IOP-lowering medication and remained in the analysis. Bim = bimatoprost; BimSR and Bimatoprost SR = bimatoprost sustained-release implant. Error bars represent standard error of the mean. American Journal of Ophthalmology 2017 175, 137-147DOI: (10.1016/j.ajo.2016.11.020) Copyright © 2016 The Author(s) Terms and Conditions

Richard A. Lewis, M.D. is the former director of glaucoma at the University of California, Davis before co-founding Sacramento Eye Consultants. He is the past President of the American Society of Cataract and Refractive Surgery (2014–15) and past President of the American Glaucoma Society (2000–02). Dr Lewis has published over 100 articles and book chapters focusing on glaucoma, ophthalmic surgery, and ophthalmic pharmacology. American Journal of Ophthalmology 2017 175, 137-147DOI: (10.1016/j.ajo.2016.11.020) Copyright © 2016 The Author(s) Terms and Conditions

Supplemental Animation Still 1 American Journal of Ophthalmology 2017 175, 137-147DOI: (10.1016/j.ajo.2016.11.020) Copyright © 2016 The Author(s) Terms and Conditions

Supplemental Animation Still 2 American Journal of Ophthalmology 2017 175, 137-147DOI: (10.1016/j.ajo.2016.11.020) Copyright © 2016 The Author(s) Terms and Conditions