Volume 151, Issue 5, Pages (May 2017)

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Volume 151, Issue 5, Pages 1069-1080 (May 2017) Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection Ivan F.N. Hung, MD, Kelvin K.W. To, MD, Jasper F.W. Chan, MBBS, Vincent C.C. Cheng, MD, Kevin S.H. Liu, MBChB, Anthony Tam, MBBS, Tuen-Ching Chan, MD, Anna Jinxia Zhang, PhD, Patrick Li, MSc, Tin-Lun Wong, BSc, Ricky Zhang, MSc, Michael K.S. Cheung, MBBS, William Leung, MBBS, Johnson Y.N. Lau, MD, Manson Fok, MD, Honglin Chen, PhD, Kwok-Hung Chan, PhD, Kwok-Yung Yuen, MD CHEST Volume 151, Issue 5, Pages 1069-1080 (May 2017) DOI: 10.1016/j.chest.2016.11.012 Copyright © 2016 American College of Chest Physicians Terms and Conditions

Figure 1 Recruitment flowchart of the 217 subjects. CrCl = creatinine clearance; CXR = chest radiograph. CHEST 2017 151, 1069-1080DOI: (10.1016/j.chest.2016.11.012) Copyright © 2016 American College of Chest Physicians Terms and Conditions

Figure 2 The 30-day survival in patients treated with the clarithromycin-naproxen-oseltamivir combination and with oseltamivir alone. CHEST 2017 151, 1069-1080DOI: (10.1016/j.chest.2016.11.012) Copyright © 2016 American College of Chest Physicians Terms and Conditions

Figure 3 Profile of virus titer after treatment. Error bars represent SEM. Significant P < .05 shown in bold. CHEST 2017 151, 1069-1080DOI: (10.1016/j.chest.2016.11.012) Copyright © 2016 American College of Chest Physicians Terms and Conditions

Figure 4 Profile of pneumonia severity index after treatment. Error bars represent SEM. Significant P < .05 shown in bold. PSI = pneumonia severity index. CHEST 2017 151, 1069-1080DOI: (10.1016/j.chest.2016.11.012) Copyright © 2016 American College of Chest Physicians Terms and Conditions

Figure 5 Percentage of patients with ≥ 5% NIRV quasispecies detected. Significant P < .05 shown in bold. NIRV = neuraminidase-inhibitor-resistant A(H3N2) virus. CHEST 2017 151, 1069-1080DOI: (10.1016/j.chest.2016.11.012) Copyright © 2016 American College of Chest Physicians Terms and Conditions