Markers and management of germ-cell tumours of the testes

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Markers and management of germ-cell tumours of the testes Prof Alan Horwich, FRCR, Robert Huddart, FRCR, David Dearnaley, FRCR The Lancet Volume 352, Issue 9139, Pages 1535-1538 (November 1998) DOI: 10.1016/S0140-6736(98)04251-2 Copyright © 1998 Elsevier Ltd Terms and Conditions

Figure Illustration of fluorescent probes to identify normal chromosome 12 and isochromosome i(12p) (a) and charged coupled device image showing the nucleus from a germ-cell tumour showing i(12p) and normal chromosome 12 (b) The size of the signal from the centromere probe (red) is different in the i(12p) and this can be seen in interphase cells. The signal from the centromere probe is flanked by signal from a 12p marker (green) in the i(12p) chromosome. The nucleus shows three copies of a normal 12 chromosome and three copies of an i(12p) chromosome (circled). The Lancet 1998 352, 1535-1538DOI: (10.1016/S0140-6736(98)04251-2) Copyright © 1998 Elsevier Ltd Terms and Conditions