Review：molecular imprinting technique （MIT） Reporters：Chen Li Zhou Qian

1992,12 articles;1999.about 150 articles; According to Mossbach reports, by the end of 1998,published MIT papers more than 500 articles Molecular imprinting Association (1997) Statistics show that at least more than 100 academic institutions and enterprises and organizations working in research and development of MIPs in the world.

1 Concept：MIT Functional monomer

2 MIT classification Molecular imprinting technology Self-assembling approach Pre-organized apporach Covalent interactions Metal coordination Non-covalent Covalent interactions Metal coordination Non-covalent Self-assembling approach Pre-organized apporach Molecular imprinting technology Molecular imprinting technology Self-assembling approach Pre-organized apporach Covalent interactions Metal coordination Non-covalent Molecular imprinting technology Self-assembling approach Pre-organized apporach Covalent interactions Metal coordination Non-covalent Molecular imprinting technology Self-assembling approach Pre-organized apporach Covalent interactions Metal coordination Non-covalent Molecular imprinting technology Self-assembling approach Pre-organized apporach Covalent interactions Metal coordination Non-covalent Molecular imprinting technology Self-assembling approach Pre-organized apporach Covalent interactions Metal coordination Non-covalent Molecular imprinting technology Molecular imprinting technology Molecular imprinting technology Molecular imprinting technology Molecular imprinting technology Molecular imprinting technology Molecular imprinting technology Molecular imprinting technology Molecular imprinting technology Molecular imprinting technology Molecular imprinting technology Molecular imprinting technology Molecular imprinting technology Molecular imprinting technology Self-assembling approach Self-assembling approach Self-assembling approach Self-assembling approach Self-assembling approach Self-assembling approach Self-assembling approach Self-assembling approach Self-assembling approach Self-assembling approach Self-assembling approach Pre-organized apporach Pre-organized apporach Pre-organized apporach Pre-organized apporach Pre-organized apporach Pre-organized apporach Pre-organized apporach Pre-organized apporach Pre-organized apporach Pre-organized apporach Metal coordination interactions Non-covalent Metal coordination interactions Non-covalent Metal coordination interactions Non-covalent Metal coordination interactions Non-covalent Metal coordination interactions Non-covalent Metal coordination interactions Non-covalent Metal coordination interactions Non-covalent Covalent interactions Covalent interactions Covalent interactions Covalent interactions Covalent interactions Covalent interactions semi-covalent imprinting polymers

3 MIT –Three characteristics predetermination recognition practicability

4 Field of application solid phase extraction membrane separation technology chromatographic separation adsorption catalytic synthesis catalytic degradation drug delivery and release

4.1 The related literature

5 challenges Biological macromolecule imprinting Heterogeneous binding sites Template leakage Incompatibility with aqueous media Low binding capacity Slow mass transfer

6 The development and prospect 1) Explore some new sythesis 2) Choose some matix materials with light ,electricity,magnetic and other more excellent performance of gold. 3) The controlled polymerization and MIT’s combination. organic phase and aqueous phase Better polymer sythesis rate of polymerization, polymerization feasibility

Thank you