Boron Neutron Capture Therapy in the Treatment of Locally Recurred Head-and-Neck Cancer: Final Analysis of a Phase I/II Trial Leena Kankaanranta, M.D.,

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Boron Neutron Capture Therapy in the Treatment of Locally Recurred Head-and-Neck Cancer: Final Analysis of a Phase I/II Trial Leena Kankaanranta, M.D., Tiina Seppälä, Ph.D., Hanna Koivunoro, M.Sci., Kauko Saarilahti, M.D., Timo Atula, M.D., Juhani Collan, M.D., Eero Salli, Ph.D., Mika Kortesniemi, Ph.D., Jouni Uusi-Simola, Ph.D., Petteri Välimäki, M.Sci., Antti Mäkitie, M.D., Marko Seppänen, M.D., Heikki Minn, M.D., Hannu Revitzer, M.Sci., Mauri Kouri, M.D., Petri Kotiluoto, Ph.D., Tom Seren, Lic. Tech, Iiro Auterinen, M.Sci., Sauli Savolainen, Ph.D., Heikki Joensuu, M.D. International Journal of Radiation Oncology • Biology • Physics Volume 82, Issue 1, Pages e67-e75 (January 2012) DOI: 10.1016/j.ijrobp.2010.09.057 Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 1 Patient accrual. BNCT = boron neutron capture therapy. International Journal of Radiation Oncology • Biology • Physics 2012 82, e67-e75DOI: (10.1016/j.ijrobp.2010.09.057) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 2 (A) Recurrent adenoid cystic carcinoma of lacrimal gland before BNCT shown in transverse (A1) and frontal (A2) MRI views. (B) Partial response after BNCT in transverse (B1) and frontal (B2) views. The arrows point at the tumor. International Journal of Radiation Oncology • Biology • Physics 2012 82, e67-e75DOI: (10.1016/j.ijrobp.2010.09.057) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 3 Recurrent squamous cell carcinoma of jaw. (A) Before BNCT. (B) Partial response after BNCT. The arrows point at the tumor. International Journal of Radiation Oncology • Biology • Physics 2012 82, e67-e75DOI: (10.1016/j.ijrobp.2010.09.057) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 4 (A) Locoregional failure-free survival, (B) progression-free survival, and (C) overall survival after BNCT. The patients censored are indicated with a bar. Two- and four-year survival figures are provided. CI = confidence interval. International Journal of Radiation Oncology • Biology • Physics 2012 82, e67-e75DOI: (10.1016/j.ijrobp.2010.09.057) Copyright © 2012 Elsevier Inc. Terms and Conditions