New β-Cell Centric Construct: Implications Genetics 101 for DM

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Presentation transcript:

New β-Cell Centric Construct: Implications Genetics 101 for DM Phenotype is DEPENDENT ON Genotype: Number of Genes- which genes- their nature, how many different ones, the ‘severity/intensity’ of expression!; epigenetics* i.e: Genes influence: B-Cell: Insulin secretory dynamics, sites of susceptibility of β-Cell to destruction by endogenous/ exogenous triggers Immune Modulation/Inflammation Insulin Resistance Environment (AND some address susceptibility to DM COMPLICATIONS) *Int J Biochem Cell Biol. 2015 May 27. pii: S1357-2725(15)00143-0. doi: 10.1016/j.biocel.2015.05.022. [Epub ahead of print] Epigenetic dynamics in immunity and autoimmunity. Zhao M1, Wang Z1, Yung S2, Lu Q. ; Understanding type 2 diabetes: from genetics to epigenetics. Raciti GA, Longo M, Parrillo L, Ciccarelli M, Mirra P, Ungaro P, Formisano P, Miele C, Béguinot F. Acta Diabetol. 2015 Apr 5.

TAK-OEC

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New β-Cell Centric Construct: Implications β-cell Issues Usual use of Glycemic Criteria- HgA1c, FBS, PPG Markers-Usual/Classic= C-Peptide New Non-Invasive β-Cell Mass Measures- Nano-particle labeled exendin imaging Circulating DNA Markers of β-Cell Destruction Glazer- Hebrew Univ Circulating mRNAs Try to Determine Mono-Genetic Causes NO LOGIC FOR USE OF AGENTS THAT MAY CONTRIBUTE TO APOPTOSIS of β-Cell STOP USING SU’s, GLINIDES; Minimize INSULIN THERAPY