The Child with an Immunologic Alteration Chapter 42 The Child with an Immunologic Alteration Elsevier items and derived items © 2013, 2009, 2005 by Saunders, an imprint of Elsevier Inc.

Nonspecific Immune Function Chemical barriers Inflammation Increased capillary permeability Vasodilation Phagocytosis Elimination of cellular waste products Elsevier items and derived items © 2013, 2009, 2005 by Saunders, an imprint of Elsevier Inc.

Specific Immune Function Humoral response Cell-mediated response Development of immunity Actively acquired Passively acquired Elsevier items and derived items © 2013, 2009, 2005 by Saunders, an imprint of Elsevier Inc.

Immunologic Imbalance Under function Increased susceptibility to infection Over function Produces antibodies against cells of the body Allergies Autoimmune disease Elsevier items and derived items © 2013, 2009, 2005 by Saunders, an imprint of Elsevier Inc.

Acquired or Congenital Immunodeficiency Increased vulnerability to viral or bacterial infections Appropriate hand hygiene and infection control practices Three guiding principles Prevent contact was organisms. Create barriers if contact is unavoidable. Kill organisms if contact is made. Elsevier items and derived items © 2013, 2009, 2005 by Saunders, an imprint of Elsevier Inc.

The Child Taking Oral Corticosteroids Both immunosuppressive and antiinflammatory properties During cessation of therapy, gradually taper the dose to allow for a gradual return of adrenal function. Elsevier items and derived items © 2013, 2009, 2005 by Saunders, an imprint of Elsevier Inc.

Immune Complex and Autoimmune Disorders Kawasaki disease Glomerulonephritis Autoimmune disorders Systemic lupus erythematosus (SLE) Elsevier items and derived items © 2013, 2009, 2005 by Saunders, an imprint of Elsevier Inc.

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Types of Allergic Reactions Type I: immediate (anaphylactic) hypersensitivity Examples: allergic rhinitis, acute anaphylaxis, hives, eczema, asthma Type II: cytotoxic hypersensitivity Examples: transfusion reaction after receiving incompatible blood Elsevier items and derived items © 2013, 2009, 2005 by Saunders, an imprint of Elsevier Inc.

Types of Allergic Reactions (cont.) Type III: arthus hypersensitivity (immune complex) Examples: serum sickness, glomerulonephritis Type IV: delayed cell-mediated hypersensitivity Examples: contact dermatitis (poison ivy) Elsevier items and derived items © 2013, 2009, 2005 by Saunders, an imprint of Elsevier Inc.

Initial Symptoms of Impending Anaphylaxis Sneezing Tightness, tingling of mouth or face, with subsequent swelling of lips and tongue Severe flushing, urticaria, and itching, especially on head and upper trunk Rapid development of erythema Sense of impending doom Elsevier items and derived items © 2013, 2009, 2005 by Saunders, an imprint of Elsevier Inc.

Managing Anaphylactic Shock Ensure an adequate airway, possibly by endotracheal intubation. Administer epinephrine. Administer oxygen if available. Administer corticosteroids and antihistamines as ordered. Keep the child warm and lying flat or with feet slightly elevated. Start an intravenous (IV) line. Elsevier items and derived items © 2013, 2009, 2005 by Saunders, an imprint of Elsevier Inc.

Question Which intervention is a priority for a nurse caring for a child with anaphylaxis? Providing supplemental oxygen Ensuring an adequate airway Initiating IV access Administering corticosteroids Answer: B Elsevier items and derived items © 2013, 2009, 2005 by Saunders, an imprint of Elsevier Inc.