Lecture 15 WEB: Go to pollev.com/ucibio TEXT: Text UCIBIO to 37607

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Presentation transcript:

Lecture 15 WEB: Go to pollev.com/ucibio TEXT: Text UCIBIO to 37607 After joining session, text your question

Lecture 15 objectives Understand role and reactions of Gluconeogenesis Apply principles of regulation to Gluconeogenesis Understand the Cori cycle Understand signaling pathways that regulate Gluconeogenesis

Maintaining blood Glc levels Glucose is the energy source for many tissues Need to keep blood glucose level constant Not taking in Glc  Blood glucose falls How to put Glc into blood?

Carbon sources for Gluconeogeneis: Cori cycle

Carbon sources for Gluconeogeneis

Gluconeogenesis Gluconeogenesis Reverse of glycolysis What step/s have to be different?

Cellular compartments Where does Glycolysis occur? Where does TCA occur?

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1: How to make PEP?

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Reversing Glycolysis

Reversing Glycolysis

Avoiding “futile” cycles

Exceptions… Glycolysis Gluconeogenesis 25°C 7°C Rate Fed animals; different temps What is the BEST explanation for these results?

Exceptions… Condition when futile cycle might be useful? Upload to “Futile cycle” Midnight tonight

Signaling cascade recap Example 2: Phosphofructokinase 2 LIVER Adenylate cyclase Low Glc ↑ cAMP ? PKA ? Pancreas ? ? Fru 2,6-bisPO4 ? PFK1; ? FBPase 1 ? GLYCOLYSIS ? GLUCONEOGENESIS

Coordinating metabolism: Recap Decreased Blood sugar Make hormone: ___________________ Effect on liver: ___________________ Effect on muscle: ___________________ Effect on adipose tissue: ___________________ Increase Blood sugar Make hormone: ___________________ Effect on liver: ___________________ Effect on muscle: ___________________ Effect on adipose tissue: ___________________