Figure 1 Normal euthymic rat (a), and congenitally athymic rnu / rnu rat (b), from the breeding colony at the National Institute of Public Health and.

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Figure 1 Normal euthymic rat (a), and congenitally athymic rnu / rnu rat (b), from the breeding colony at the National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands. Note the hairlessness (that is not complete) in the rat with the rnu mutation. (Photograph courtesy of the authors.) The rnu (Rowett Nude) and rnuN ( nznu, New Zealand Nude) Rat: An Update ILAR J. 1992;34(1-2):3-12. doi:10.1093/ilar.34.1-2.3 ILAR J | © Institute for Laboratory Animal Research

Formalin-fixed material, embedded in paraffin, secion stained with hematoxylin and cosin. (Photograph courtesy of the authors. The rnu (Rowett Nude) and rnuN ( nznu, New Zealand Nude) Rat: An Update ILAR J. 1992;34(1-2):3-12. doi:10.1093/ilar.34.1-2.3 ILAR J | © Institute for Laboratory Animal Research

(a) There is no specific immunolabeling for αβ-T-cell receptor; the black dots, mainly in the red pulp, represent endogenous peroxidase activity. (b) Around the arteriole some cells are labeled by ER2 (indicated by arrows), and in addition a diffuse immunolabeling for ER2 is observed in the red pulp; this immunolabeling presumably represents macrophage staining. (c) Some cells in the white pulp, and at a higher density cells in the red pulp show immunolabeling by OX8 (some indicated by arrows), presumably representing labeling of natural-killer cells. (d) Macrophages in the white pulp, especially around the arteriole, and in the red pulp are labeled by ED1. (Photographs courtesy of the authors). The rnu (Rowett Nude) and rnuN ( nznu, New Zealand Nude) Rat: An Update ILAR J. 1992;34(1-2):3-12. doi:10.1093/ilar.34.1-2.3 ILAR J | © Institute for Laboratory Animal Research