Metabolism in Nervous Tissue

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Presentation transcript:

Metabolism in Nervous Tissue 5/20/2018 Metabolism in Nervous Tissue Glycolysis Glycogenolysis (stress) -oxidation (ketone bodies) Krebs (tricarboxylic acid) cycle Branched-chain amino acids Electron transport chain Eric Niederhoffer SIU-SOM

Pathways Overview Production of ATP G6P Glucose Pyruvate Ketone bodies 5/20/2018 Pathways Overview Glycolysis G6P Glucose Pyruvate Ketone bodies Fatty acids b-oxidation Glycogen Glycogenolysis Lactate (glial) Lactate No O2 Acetyl-CoA Krebs cycle Electron Transport Chain G6P: glucose-6-phosphate BCAA: branched-chain amino acids Ile: isoleucine & Val: valine (enter as succinyl CoA); Leu: leucine (enters as acetyl CoA) ATP: adenosine triphosphate Ketone bodies come from from liver Maple syrup urine disease results from defect in branched chain -keto acid dehydrogenase complex; special diet needed; 4 children in St. Louis. GLUT1, GLUT3 in nervous tissue Brain accounts for 25% total body Glc utilization Energy - 80% from Glc, up to 20% from ketone bodies, 5% from glycogen (main stores are astrocytes) Astrocytes make lactate or pyruvate, which does not cross blood brain barrier Unsaturated fatty acids can go through BBB (astrocytes do -oxidation, mitochondrial and peroxisomal) BCAA Ile, Leu, Val Production of ATP

5/20/2018 Review Questions How does nervous tissue (neurons and glial cells) produce ATP (carbohydrates, fatty acids, ketone bodies, branched-chain amino acids)? How do glial cells (astrocytes) assist neurons?