Volume 375, Issue 9729, Pages (May 2010)

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Volume 375, Issue 9729, Pages 1885-1895 (May 2010) Supervised injectable heroin or injectable methadone versus optimised oral methadone as treatment for chronic heroin addicts in England after persistent failure in orthodox treatment (RIOTT): a randomised trial Prof John Strang, MD, Nicola Metrebian, PhD, Nicholas Lintzeris, PhD, Laura Potts, MSc, Tom Carnwath, MRCPsych, Soraya Mayet, MRCPsych, Hugh Williams, MRCPsych, Deborah Zador, MD, Richard Evers, MSc, Teodora Groshkova, PhD, Vikki Charles, MA, Anthea Martin, BSc, Luciana Forzisi, DClinPsych The Lancet Volume 375, Issue 9729, Pages 1885-1895 (May 2010) DOI: 10.1016/S0140-6736(10)60349-2 Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile The Lancet 2010 375, 1885-1895DOI: (10.1016/S0140-6736(10)60349-2) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 2 Rates of retention in treatment for the intention-to-treat sample (A) and the sample of participants who received treatment (B) The Lancet 2010 375, 1885-1895DOI: (10.1016/S0140-6736(10)60349-2) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 3 Mean daily dose of treatment Dose data are available only for patients who received treatment. The Lancet 2010 375, 1885-1895DOI: (10.1016/S0140-6736(10)60349-2) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 4 Proportion of responders* at weeks 14–26 Error bars are 95% CIs. Analysis adjusted for centre, regular crack use at baseline, and treatment with optimised oral methadone at baseline. *50% or more of urine samples negative for street heroin during weeks 14–26. The Lancet 2010 375, 1885-1895DOI: (10.1016/S0140-6736(10)60349-2) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 5 Proportion of participants who were abstinent* from street heroin at weeks 23–26 Error bars are 95% CIs. Analysis adjusted for centre, regular crack use at baseline, and treatment with optimised oral methadone at baseline. *Negative results in all four samples taken in weeks 23–26. The Lancet 2010 375, 1885-1895DOI: (10.1016/S0140-6736(10)60349-2) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 6 Proportion of participants abstinent from street heroin per week by data for urine drug screen (intention-to-treat sample) The Lancet 2010 375, 1885-1895DOI: (10.1016/S0140-6736(10)60349-2) Copyright © 2010 Elsevier Ltd Terms and Conditions