L-Boronophenylalanine-Mediated Boron Neutron Capture Therapy for Malignant Glioma Progressing After External Beam Radiation Therapy: A Phase I Study

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l-Boronophenylalanine-Mediated Boron Neutron Capture Therapy for Malignant Glioma Progressing After External Beam Radiation Therapy: A Phase I Study Leena Kankaanranta, M.D., Tiina Seppälä, Ph.D., Hanna Koivunoro, M.Sci., Petteri Välimäki, M.Sci, Annette Beule, M.D., Juhani Collan, M.D., Mika Kortesniemi, Ph.D., Jouni Uusi-Simola, Ph.D., Petri Kotiluoto, Ph.D., Iiro Auterinen, M.Sci., Tom Serèn, Lic.Tech., Anders Paetau, M.D., Kauko Saarilahti, M.D., Sauli Savolainen, Ph.D., Heikki Joensuu, M.D. International Journal of Radiation Oncology • Biology • Physics Volume 80, Issue 2, Pages 369-376 (June 2011) DOI: 10.1016/j.ijrobp.2010.02.031 Copyright © 2011 Elsevier Inc. Terms and Conditions

Fig. 1 Survival after administration of BNCT. A patient alive at the time of the analysis is shown with a bar. International Journal of Radiation Oncology • Biology • Physics 2011 80, 369-376DOI: (10.1016/j.ijrobp.2010.02.031) Copyright © 2011 Elsevier Inc. Terms and Conditions

Fig. 2 Exploratory survival analyses based on the l-BPA-F dose delivered (A) and the estimated median planning target volume (PTV) dose administered (B). A patient alive at the time of the analysis is shown with a bar. International Journal of Radiation Oncology • Biology • Physics 2011 80, 369-376DOI: (10.1016/j.ijrobp.2010.02.031) Copyright © 2011 Elsevier Inc. Terms and Conditions