A molecular epidemiological study of human parainfluenza virus type 3 at a tertiary university hospital during 2013–2015 in Catalonia, Spain Cristina.

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A molecular epidemiological study of human parainfluenza virus type 3 at a tertiary university hospital during 2013–2015 in Catalonia, Spain Cristina Godoy, Paula Peremiquel-Trillas, Cristina Andrés, Laura Gimferrer, Sonia María Uriona, María Gema Codina, Lluis Armadans, María del Carmen Martín, Francisco Fuentes, Juliana Esperalba, Magda Campins, Tomàs Pumarola, Andrés Antón Diagnostic Microbiology and Infectious Disease Volume 86, Issue 2, Pages 153-159 (October 2016) DOI: 10.1016/j.diagmicrobio.2016.07.023 Copyright © 2016 Elsevier Inc. Terms and Conditions

Fig. 1 Weekly distribution of laboratory-confirmed HPIV-3 cases detected from week 40/2013 (2013–2014 season) to week 20/2015 (2014–2015 season). Diagnostic Microbiology and Infectious Disease 2016 86, 153-159DOI: (10.1016/j.diagmicrobio.2016.07.023) Copyright © 2016 Elsevier Inc. Terms and Conditions

Fig. 2 Phylogenetic analysis based on the coding sequence of the HN protein (1719 nucleotides) from 94 HPIV-3 strains of the present study and other reference sequences. The evolutionary distances were computed using Tamura-Nei method and are in the units of the number of base substitutions per site. The rate variation among sites was modeled with a gamma distribution (0.28). Only bootstrap values higher than 70% are shown. Novel lineage described C1c (*) are also included. Strains associated with suspected nosocomial outbreaks are indicated as [N] followed by different letters relative to the affected hospital ward (H-hematology, O-oncohaematology, N-neonatology). Amino acid substitution within the antigenic epitopes (*) or the binding receptor site (**), are marked underlined. Diagnostic Microbiology and Infectious Disease 2016 86, 153-159DOI: (10.1016/j.diagmicrobio.2016.07.023) Copyright © 2016 Elsevier Inc. Terms and Conditions

Fig. 3 Phylogenetic analysis based on the partial sequence of the F gene (390 nucleotides) from 97 HPIV-3 strains of the present study. The evolutionary distances were computed using Tamura-Nei method and are in the units of the number of base substitutions per site. The rate variation among sites was modeled with a gamma distribution (0,97). Only bootstrap values higher than 70% are shown. Novel lineage described C1c(*) are also included. Strains associated with suspected nosocomial outbreaks are indicated as [N] followed by different letters relative to the affected hospital ward (H-hematology, O-oncohaematology, N-neonatology). (F) Strains characterized only by the F protein. Diagnostic Microbiology and Infectious Disease 2016 86, 153-159DOI: (10.1016/j.diagmicrobio.2016.07.023) Copyright © 2016 Elsevier Inc. Terms and Conditions

Fig. 4 Chronological appearance of the suspected HPIV-3 nosocomial clusters by phylogenetic analyses with (dark gray) or without (light gray) epidemiological confirmation. With a plus (+) the date of HPIV-3 laboratory-confirmation. Diagnostic Microbiology and Infectious Disease 2016 86, 153-159DOI: (10.1016/j.diagmicrobio.2016.07.023) Copyright © 2016 Elsevier Inc. Terms and Conditions

Supplementary Fig. 1 Distribution of strains belonging to the different phylogenetic groups and subgroups by seasonal and inter-seasonal periods. Diagnostic Microbiology and Infectious Disease 2016 86, 153-159DOI: (10.1016/j.diagmicrobio.2016.07.023) Copyright © 2016 Elsevier Inc. Terms and Conditions