Volume 108, Issue 10, Pages 1853-1863 (December 2014) Alterations of 5-HT1A receptor-induced G-protein functional activation and relationship to memory deficits in patients with pharmacoresistant temporal lobe epilepsy  Manola Cuellar-Herrera, Ana Luisa Velasco, Francisco Velasco, David Trejo, Mario Alonso-Vanegas, Avril Nuche-Bricaire, Daruni Vázquez-Barrón, Rosalinda Guevara-Guzmán, Luisa Rocha  Epilepsy Research  Volume 108, Issue 10, Pages 1853-1863 (December 2014) DOI: 10.1016/j.eplepsyres.2014.09.013 Copyright © 2014 Elsevier B.V. Terms and Conditions

Fig. 1 (A) Representation of absolute [35S]GTPγS basal binding obtained from autopsies and epileptic patients. Values are represented as mean±S.E.M. of fmol/mg of protein. (B) Specific [35S]GTPγS binding to membranes of samples from autopsies (--■--) and from patients with mTLE (-□-) as a function of increasing concentration of the 5-HT1A receptor agonist 8-OH-DPAT. Each point represents the mean±S.E.M of the fmol/mg of protein stimulation over basal values. Note that in patients with mTLE, [35S]-GTPγS binding stimulation by 8-OH-DPAT was significantly different from that of autopsy samples. Epilepsy Research 2014 108, 1853-1863DOI: (10.1016/j.eplepsyres.2014.09.013) Copyright © 2014 Elsevier B.V. Terms and Conditions

Fig. 2 Representation of correlation of Emax [35S]GTPγS binding with (A) immediate recall memory scores (Rey–Osterrieth complex figure) and (B) delayed recall memory scores (word list recognition and Rey–Osterrieth complex figure). Note that we found a significant negative correlation of 5-HT1A receptor-induced G-protein functional activation with visual learning (immediate recall memory) and verbal and visual memory retrieval (delayed recall memory). Epilepsy Research 2014 108, 1853-1863DOI: (10.1016/j.eplepsyres.2014.09.013) Copyright © 2014 Elsevier B.V. Terms and Conditions