A Dose Escalation and Pharmacodynamic Study of Triapine and Radiation in Patients With Locally Advanced Pancreas Cancer Ludmila Katherine Martin, MD,

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A Dose Escalation and Pharmacodynamic Study of Triapine and Radiation in Patients With Locally Advanced Pancreas Cancer Ludmila Katherine Martin, MD, John Grecula, MD, Guang Jia, MD, Lai Wei, PhD, Xiangyu Yang, MD, Gregory A. Otterson, MD, Xin Wu, MD, Erica Harper, BS, Cheryl Kefauver, BS, Bing-Sen Zhou, MD, Yun Yen, MD, Mark Bloomston, MD, Michael Knopp, MD, S. Percy Ivy, MD, Michael Grever, MD, Tanios Bekaii-Saab, MD International Journal of Radiation Oncology • Biology • Physics Volume 84, Issue 4, Pages e475-e481 (November 2012) DOI: 10.1016/j.ijrobp.2012.06.003 Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig Waterfall plot of response in the primary tumor (A) and RECIST response in all patients and by dosage level (B). PD = progressive disease; SD = stable disease; PR = partial response. (◊) Denotes patients with 0% change as maximum response. International Journal of Radiation Oncology • Biology • Physics 2012 84, e475-e481DOI: (10.1016/j.ijrobp.2012.06.003) Copyright © 2012 Elsevier Inc. Terms and Conditions