Politis A, Theleritis C, Soldatos C, Psarros C, Papadimitriou GN Adjunctive use of amisulpride in elderly patients with psychotic depression treated with antidepressants. Politis A, Theleritis C, Soldatos C, Psarros C, Papadimitriou GN Athens University Medical School, 1st Psychiatry Dept., Athens, Greece. Results In 5 of the 11 patients there was remission of depression, while in another 5 patients there was partial remission of depression and in one patient there was no remission. Finally, there was resolution of psychotic symptoms in all the patients involved. One patient developed tremor and rigidity but insisted on continuing with the drug since her psychopathology was considerably improved after the addition of amisulpride to antidepressant treatment. Background Psychotic depression is classified as a clinical subtype of major depressive disorder. The combination of an antidepressant with an antipsychotic agent has been demonstrated to be efficacious for the treatment of psychotic depression. However, in elderly patients with psychotic depression, little information is available on the efficacy of such combinations. Therefore, we have evaluated combination treatment for five weeks with amisulpride and antidepressants in non-demented elderly patients with psychotic depression. Material-Methods At first eleven patients were treated with either citalopram 20-40 mg/day (n=5) or mirtazapine 30-60 mg/day (n=6) for 4-6 weeks, and later when psychotic symptoms persisted amisulpride 75-100mg/day was added for 5 weeks. Clinical status was evaluated at baseline and after three and five weeks using the Brief Psychiatric Rating Scale (BPRS), the Hamilton Depression Rating Scale- 17 items (HDRS) and the Clinical Global Impression Scale (CGI-S). Conclusion Some elderly patients with psychotic depression may benefit from the combination of amisulpride and antidepressant pharmacotherapy. References Leucht S. Amisulpride- a selective dopamine antagonist and atypical antipsychotic: results of a meta-analysis of randomized controlled trials. Int J Neuropsychopharmacol 2004; 7(Suppl 1):15-20. Mulsant BH, Sweet RA, Rosen J, Pollock BG, Zubenko GS, Flynn T, et al. A double-blind randomized comparison of nortriptyline plus perphenazine versus nortriptyline plus placebo in the treatment of psychotic depression in late life. J Clin Psychiatry 2001;62:597–604.