Metabolic pathways for the formation and disposal of adenine and adenosine in humans, compared with those for hypoxanthine. Adenine phosphoribosyltransferase.

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Metabolic pathways for the formation and disposal of adenine and adenosine in humans, compared with those for hypoxanthine. Adenine phosphoribosyltransferase (APRT) catalyzes the synthesis of AMP from adenine and 5-phosphoribosyl-1-pyrophosphate (PP-ribose-P) in the presence of Mg2++. In APRT deficiency, adenine is oxidized, via 8-hydroxyadenine (8-HA), to 2,8-dihydroxyadenine (2,8-DHA) by XDH. Adenine is formed, as a by-product of polyamine synthesis, from 5′-methylthioadenosine by the action of 5′-methylthioadenosine phosphorylase (MTAP). This is probably the principal route of adenine formation in vivo. A novel route of adenine formation involving S-adenosylhomocysteine hydrolase (SAHH) is indicated by the dotted line. Source: Adenine Phosphoribosyltransferase Deficiency and 2,8-Dihydroxyadenine Lithiasis, The Online Metabolic and Molecular Bases of Inherited Disease Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: https://ommbid.mhmedical.com/DownloadImage.aspx?image=/data/books/971/ch108fg1.png&sec=62635614&BookID=971&ChapterSecID=62635610&imagename= Accessed: October 15, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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