Stem Cell doubling is logarithmic

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Presentation transcript:

Stem Cell doubling is logarithmic jyt-stemcells.com Stem Cell doubling is logarithmic

Adult versus Umbilical Cord Blood Stem Cells jyt-stemcells.com Adult versus Umbilical Cord Blood Stem Cells

Stem Cell doubling times jyt-stemcells.com Stem Cell doubling times Hong-Xing Chang, MD et al. Age related Biological Characterization of Mesenchymal Progenitor Cells in Human Cartilage. Orthopedics | August 2011 – Volume 34 . Issue B: e382 – e 388 Doubling time (h, X±S) Starting with a single cell, cultured over 30 days….

Effects of Aging on Stem Cells jyt-stemcells.com Effects of Aging on Stem Cells Indices of aging including oxidative damage, ROS levels and p21 and p53 all increased suggesting a loss of stem cell fitness with age. hMSC numbers obtained by marrow aspiration decline with age. There is an age-related decline in overall stem cell “fitness” which might lead to problems when using autologous aged MSC for cell based therapies.

Umbilical Cord Blood Safety jyt-stemcells.com Umbilical Cord Blood Safety JYT transplants Lancet 2003 J Am Coll Surg 2005 Thousands of transplants at JYT – no single case of GVHD 413 units of cord blood given, no adverse effects 128 patients given cord blood – no adverse effects

HUCB Stem Cells – USFDA Approved Uses (2014) jyt-stemcells.com HUCB Stem Cells – USFDA Approved Uses (2014) fda.gov/2014Updates Cord blood is approved only for use in “hematopoietic stem cell transplantation” procedures, which are done in patients with disorders affecting the hematopoietic (blood forming) system. Cord blood contains blood-forming stem cells that can be used in the treatment of patients with blood cancers such as leukemias and lymphomas, as well as certain disorders of the blood and immune systems. “Cord blood is useful because it is a source of stem cells that form into blood cells. Cord blood can be used for transplantation in people who need regeneration, that is, ‘regrowth,’ of these blood-forming cells,” - Wonnacott

How Umbilical Cord Blood MSCs work jyt-stemcells.com How Umbilical Cord Blood MSCs work

Upgrade to HUCB Stem Cell Extraction Technology jyt-stemcells.com Upgrade to HUCB Stem Cell Extraction Technology Your partner in optimizing therapy efficacy and patient benefit