Volume 139, Issue 6, Pages 1961-1971.e1 (December 2010) Splanchnic Balance of Free Fatty Acids, Endocannabinoids, and Lipids in Subjects With Nonalcoholic Fatty Liver Disease  Jukka Westerbacka, Anna Kotronen, Barbara A. Fielding, John Wahren, Leanne Hodson, Julia Perttilä, Tuulikki Seppänen–Laakso, Tapani Suortti, Johanna Arola, Rolf Hultcrantz, Sandra Castillo, Vesa M. Olkkonen, Keith N. Frayn, Matej Orešič, Hannele Yki–Järvinen  Gastroenterology  Volume 139, Issue 6, Pages 1961-1971.e1 (December 2010) DOI: 10.1053/j.gastro.2010.06.064 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 Effect of insulin on whole- body and splanchnic FFA and 3-OHB production, and glycerol release. *P < .05; **P < .01. Gastroenterology 2010 139, 1961-1971.e1DOI: (10.1053/j.gastro.2010.06.064) Copyright © 2010 AGA Institute Terms and Conditions

Figure 2 (A) The relationship between FFA extraction during hyperinsulinemia and liver fat content. (B) Correlation coefficients between splanchnic production of each of the 85 individual TGs and liver fat content were calculated. These correlation coefficients (Spearman rho) then were plotted against the number of double bonds in the respective TGs. An inverse relationship was observed, implying that the higher the liver fat, the less TGs, which contain many double bonds that are produced by the splanchnic region. Gastroenterology 2010 139, 1961-1971.e1DOI: (10.1053/j.gastro.2010.06.064) Copyright © 2010 AGA Institute Terms and Conditions

Figure 3 Arterial and hepatic venous concentrations of (A) anandamide and (B) 2-arachidonoylglycerol (2-ag). The relationships between liver fat and (C) arterial and (D) hepatic venous concentrations of 2-AG. *P < .05. Gastroenterology 2010 139, 1961-1971.e1DOI: (10.1053/j.gastro.2010.06.064) Copyright © 2010 AGA Institute Terms and Conditions