In vivo toxicity of cationic micelles and liposomes

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Presentation transcript:

In vivo toxicity of cationic micelles and liposomes Kristina Bram Knudsen, PhD, Helle Northeved, DVM, PhD, Pramod Kumar EK, PhD, Anders Permin, DVM, PhD, Torben Gjetting, PhD, Thomas L. Andresen, PhD, Steen Larsen, DVM, PhD, Karen Malene Wegener, DVM, PhD, Jens Lykkesfeldt, PhD, DSc, Kim Jantzen, MSc, Steffen Loft, MD, Peter Møller, PhD, Martin Roursgaard, PhD Nanomedicine: Nanotechnology, Biology and Medicine Volume 11, Issue 2, Pages 467-477 (February 2015) DOI: 10.1016/j.nano.2014.08.004 Copyright © 2015 The Authors. Terms and Conditions

Figure 1 DNA damage observed in the 7day repeated dose study. Rats were exposed to either PBS as control vehicle (dark bars), micelles (light grey) or liposomes (dark grey). Data are represented as strand breaks (SB) or FPG sensitive sites (FPGss) in lung (A) and liver (B). Data are reported as mean level of 8 animals+SEM. * indicate that P<0.05 compared to the control group. Nanomedicine: Nanotechnology, Biology and Medicine 2015 11, 467-477DOI: (10.1016/j.nano.2014.08.004) Copyright © 2015 The Authors. Terms and Conditions

Figure 2 mRNA level observed in the 7day repeated dose study in the liver tissue. Rats exposed to either PBS as control vehicle (dark bars), micelles (light grey) or liposomes (dark grey). The level of the following genes is reported: CCL2 (A); CXCL2 (B); HMOX1 (C); IL6 (D) and OGG1 (E). Data are reported as mean level of 8 animals+SEM. * indicate that p<0.05 compared to the control group. Nanomedicine: Nanotechnology, Biology and Medicine 2015 11, 467-477DOI: (10.1016/j.nano.2014.08.004) Copyright © 2015 The Authors. Terms and Conditions

Figure 3 mRNA level observed in the 7day repeated dose study in the lung tissue. Rats exposed to either PBS as control vehicle (dark bars), micelles (light grey) or liposomes (dark grey). The level of the following genes is reported: CCL2 (A); CXCL2 (B); HMOX1 (C); IL6 (D) and OGG1 (E). Data are reported as mean level of 8 animals+SEM. * indicate that p<0.05 compared to the control group. Nanomedicine: Nanotechnology, Biology and Medicine 2015 11, 467-477DOI: (10.1016/j.nano.2014.08.004) Copyright © 2015 The Authors. Terms and Conditions

Figure 4 DNA damage observed in the single dose study in the lungs (A & B) and the spleen (C & D) represented as strand breaks (SB) (A & C) and FPG sensitive sites (FPGss) (B & D). Dashed bars are after 48h. Data are reported as mean level of 8 animals+SEM. * indicate that p<0.05 compared to the control group. Nanomedicine: Nanotechnology, Biology and Medicine 2015 11, 467-477DOI: (10.1016/j.nano.2014.08.004) Copyright © 2015 The Authors. Terms and Conditions

Nanomedicine: Nanotechnology, Biology and Medicine 2015 11, 467-477DOI: (10.1016/j.nano.2014.08.004) Copyright © 2015 The Authors. Terms and Conditions