Volume 96, Pages (November 2015)

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Volume 96, Pages 310-316 (November 2015) Impact of time to return of spontaneous circulation on neuroprotective effect of targeted temperature management at 33 or 36 degrees in comatose survivors of out-of hospital cardiac arrest Jesper Kjaergaard, Niklas Nielsen, Matilde Winther-Jensen, Michael Wanscher, Tommaso Pellis, Michael Kuiper, Jakob Hartvig Thomsen, Jørn Wetterslev, Tobias Cronberg, John Bro-Jeppesen, David Erlinge, Hans Friberg, Helle Søholm, Yvan Gasche, Janneke Horn, Jan Hovdenes, Pascal Stammet, Matthew P. Wise, Anders Åneman, Christian Hassager Resuscitation Volume 96, Pages 310-316 (November 2015) DOI: 10.1016/j.resuscitation.2015.06.021 Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Top panel: Smooth spline plot of estimated hazard of death to time to return of spontaneous circulation, 95% confidence intervals shown as dotted lines. Individual observations indicated as dots above the x-axis and quartiles of time to ROSC indicated by vertical lines. No difference in the two TTM allocation strata was found, pinteraction=0.11. Lover panel: Mortality in 8 strata defined by quartiles of time to ROSC and target temperature allocation group. Differences tested by log rank test in the four time to ROSC strata, overall no significant interaction was found when adjusting for potential confounders, pinteraction=0.11. Resuscitation 2015 96, 310-316DOI: (10.1016/j.resuscitation.2015.06.021) Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Top panels: Actual survival in comatose patients resuscitated from out of hospital cardiac arrest, stratified by quartiles of time to return of spontaneous circulation (ROSC). The thirty-day survival is shown in left panel (A), long-term survival in the right panel (B). Differences tested by log rank test, p<0.001 for both. Lower panels: Neurological deaths stratified by quartiles of time to return of spontaneous circulation (ROSC) with short term survival in left panel (C) and long-term in the right panel (D). Differences between 33 and 36C tested by logrank test, p=0.96, p=0.27, p=0.36, p=0.82 for quartiles 1–4. Resuscitation 2015 96, 310-316DOI: (10.1016/j.resuscitation.2015.06.021) Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Neurological outcome assessed by Cerebral Performance Category (CPC), left panel, and modified Rankin Scale (mRS), right panel by quartiles of time to return of spontaneous circulation. Resuscitation 2015 96, 310-316DOI: (10.1016/j.resuscitation.2015.06.021) Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions