S3 Fig Inactivity of inhibitors of reverse transcriptase and integrase

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S3 Fig Inactivity of inhibitors of reverse transcriptase and integrase NVP Nevirapine – NNRTI, non-nucleotide reverse transcriptase inhibitor AZT Azidothymidine – NRTI, nucleoside analogue reverse transcriptase inhibitor A B 24 h 48 h 240 220 200 180 160 140 Relative copy number of provirus Positive-strand HIV-1 DNA (copies/1 ng genomic DNA) 120 100 80 60 40 20 ♯1 ♯2 ♯1 ♯2 ♯1 ♯2 ♯1 ♯2 - NVP + NVP - AZT + AZT - AZT + AZT 118-D-24 Integrase inhibitor; azido-, diketo acid derivative – blocks DNA strand transfer C D Relative copy number of provirus - 118D24 + 118D24 E ♯1 ♯2 ♯1 ♯2 2 4 6 8 10 12 14 16 p24, ng/ml AZT, 3µM NL4-3(VSVG) NVP, 10µM + _ Relative copy number of provirus - NVP + NVP