The value of 3.0Tesla diffusion-weighted MRI for pelvic nodal staging in patients with early stage cervical cancer W.M. Klerkx, W.B. Veldhuis, A.M. Spijkerboer,

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The value of 3.0Tesla diffusion-weighted MRI for pelvic nodal staging in patients with early stage cervical cancer W.M. Klerkx, W.B. Veldhuis, A.M. Spijkerboer, M.A. van den Bosch, W.P. Mali, A.P. Heintz, S. Bipat, D.M. Sie-Go, J. van der Velden, H.W. Schreuder, J. Stoker, P.H. Peeters European Journal of Cancer Volume 48, Issue 18, Pages 3414-3421 (December 2012) DOI: 10.1016/j.ejca.2012.06.022 Copyright © 2012 Elsevier Ltd Terms and Conditions

Fig. 1 A) Axial T2-weighted SPAIR, fused with DWI (b=1000s/m2). Para-iliac lymph nodes are highlighted and easier to detect. (B) Axial T2-weighted SPAIR without the fusion image. (C) Apparent diffusion coefficient (ADC) map of this slice. (D) ADC measurement of the highlighted lymph node: a manually placed region of interest (ROI). (E) The ROI is then copied to the ADC map and manually adjusted if necessary. European Journal of Cancer 2012 48, 3414-3421DOI: (10.1016/j.ejca.2012.06.022) Copyright © 2012 Elsevier Ltd Terms and Conditions

Fig. 2 Flowchart of included patients. European Journal of Cancer 2012 48, 3414-3421DOI: (10.1016/j.ejca.2012.06.022) Copyright © 2012 Elsevier Ltd Terms and Conditions

Fig. 3 Receiver operating characteristic (ROC) curves of morphological characteristics on conventional MRI. AUC short axis diameter with 95% Confidence Interval (CI): 0.81 (0.70–0.91). AUC long axis diameter with 95% CI: 0.69 (0.54–0.84). AUC ratio short:long axis diameter with 95% CI: 0.67 (0.54–0.79). AUC apparent diffusion coefficient (ADC) with 95% CI: 0.62 (0.48–0.76). European Journal of Cancer 2012 48, 3414-3421DOI: (10.1016/j.ejca.2012.06.022) Copyright © 2012 Elsevier Ltd Terms and Conditions