Volume 359, Issue 9317, Pages 1575-1577 (May 2002) Proteinuria and prenatal diagnosis of congenital nephrosis in fetal carriers of nephrin gene mutations  Jaakko Patrakka, MD, Paula Martin, PhD, Riitta Salonen, MD, Marjo Kestilä, PhD, Vesa Ruotsalainen, MSc, Minna Männikkö, PhD, Markku Ryynänen, MD, Juhani Rapola, MD, Christer Holmberg, MD, Karl Tryggvason, MD, Dr Hannu Jalanko, MD  The Lancet  Volume 359, Issue 9317, Pages 1575-1577 (May 2002) DOI: 10.1016/S0140-6736(02)08504-5 Copyright © 2002 Elsevier Ltd Terms and Conditions

Figure 1 Fetal kidneys with normal NPHS1 genotype (A), Fin-major/Fin-minor genotype (B), and Fin-major heterozygote (C) End=endothelium, gbm=glomerular basement membrane, fp=podocyte foot processes, sd=slit diaphragms (arrows), us=urinary space. Arrowhead=microcysts. *=kidney capsule. Bars: 500 nm (top plate in all three panels) and 80 nm (bottom left plate in all three panels): magnifications ×80 (bottom middle all three panels), ×400 (bottom right all three panels). The Lancet 2002 359, 1575-1577DOI: (10.1016/S0140-6736(02)08504-5) Copyright © 2002 Elsevier Ltd Terms and Conditions

Figure 2 Serum alpha-fetoprotein (AFP) concentrations in maternal serum (A) and amniotic fluid (B) The Lancet 2002 359, 1575-1577DOI: (10.1016/S0140-6736(02)08504-5) Copyright © 2002 Elsevier Ltd Terms and Conditions