Volume 44, Issue 1, Pages (February 2017)

Slides:

Advertisements

Similar presentations

Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.

Advertisements

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

Distribution of Human Embryonic Stem Cell Lines: Who, When, and Where Jennifer B. McCormick, Jason Owen-Smith, Christopher Thomas Scott Cell Stem Cell.

Cancer Metabolism Cell Volume 148, Issue 3, (February 2012) DOI: /j.cell Copyright © 2012 Terms and Conditions Terms and Conditions.

IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:

ABO-incompatible kidney transplantation Kota Takahashi, Kazuhide Saito Transplantation Reviews Volume 27, Issue 1, Pages 1-8 (January 2013) DOI: /j.trre

Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.

A new soy germ fermented ingredient displays estrogenic and protease inhibitor activities able to prevent irritable bowel syndrome-like symptoms in stressed.

Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities Koen Schepers, Timothy B. Campbell, Emmanuelle Passegué Cell Stem Cell Volume.

Volume 120, Issue 4, Pages (March 2001)

Controversies in multiple myeloma: Evidence-based update

Volume 136, Issue 1, Pages (July 2015)

Samuel Yeung Shan Wong, Dicken C.C. Chan, Athena Hong, Jean Woo

The organization of the health care provider's practice influenced patient participation in research: a multilevel analysis Laurent Rigal, Marie-Joseph.

Gemcitabine plus cisplatin versus chemoradiotherapy in locally advanced biliary tract cancer: Fédération Francophone de Cancérologie Digestive 9902 phase.

MET Gene Copy Number in Non-small Cell Lung Cancer: Molecular Analysis in a Targeted Tyrosine Kinase Inhibitor Naïve Cohort Michèle Beau-Faller, MD,

Volume 17, Issue 5, Pages (May 2016)

Raynaud's Phenomenon of the Lung

Volume 356, Issue 9232, Pages (September 2000)

Comparison of the efficacy and safety of single-agent and doublet chemotherapy in advanced non-small cell lung cancer in the elderly: A meta-analysis

Building better therapy for children with acute lymphoblastic leukemia

Jochen G. Schneider, Joseph H. Nadeau Cell Metabolism

Preface Surgical Oncology Clinics

Jagadeesh Bayry, Jean-François Gautier Cell Metabolism

Pancreatic enzyme replacement therapy for young cystic fibrosis patients Anne Munck, Jean-Francois Duhamel, Thierry Lamireau, Bernard Le Luyer, Claire.

Are patients willing to travel for better ovarian cancer care?

Resistance in the Ribosome: RUNX1, pre-LSCs, and HSPCs

Personalized Disease Models on a Chip

Stressed-Out HSCs Turn Up p38α and Purine to Proliferate

A Radical Role for p38 MAPK in Tumor Initiation

Transplacental maternal engraftment and posttransplantation graft-versus-host disease in children with severe combined immunodeficiency Justin Wahlstrom,

Clinical Image Quality and Sensitivity in an Organized Mammography Screening Program Isabelle Théberge, PhD, Marie-Hélène Guertin, MSc, PhD, Nathalie.

Reversal of Overanticoagulation in Very Elderly Hospitalized Patients with an INR above 5.0: 24-Hour INR Response after Vitamin K Administration Eric.

Resistance in the Ribosome: RUNX1, pre-LSCs, and HSPCs

Jan Philipp Junker, Alexander van Oudenaarden Molecular Cell

Adult-Onset Homocystinuria Arteriopathy Mimics Fibromuscular Dysplasia

Jean-Pierre Van Buyten, MD Journal of Pain and Symptom Management

Gradients Are Shaping Up

Why We Should Put Clothes on Mice

Loukia Yiangou, Alexander D.B. Ross, Kim Jee Goh, Ludovic Vallier

The applicability of urinary creatinine as a method of specimen normalization in the cystic fibrosis population Brandie D. Wagner, Frank J. Accurso,

Volume 120, Issue 4, Pages (March 2001)

Should Nurses' Undergraduate Training Be in the Humanities?

Personalized Disease Models on a Chip

Modifying Mitochondrial tRNAs: Delivering What the Cell Needs

Volume 152, Issue 1, Pages (January 2019)

Volume 150, Issue 4, Pages e8 (April 2016)

Boosting Signal-to-Noise in Complex Biology: Prior Knowledge Is Power

A Post Hoc Sensitivity Analysis of Survival Probabilities in a Multinational Phase III Trial of Decitabine in Older Patients With Newly Diagnosed Acute.

Rewiring Bacteria, Two Components at a Time

Neuropsychological Assessment of Sport-Related Concussion

Modified antigenic reactivity of anti-phospholipase A2 IgG antibodies in patients allergic to bee venom: Conversion with immunotherapy and relation to.

NO Signals from the Cancer Stem Cell Niche

Volume 17, Issue 2, Pages (February 1950)

J.E. Spahr, R.B. Love, M. Francois, K. Radford, K.C. Meyer

The Plasticity of Aging: Insights from Long-Lived Mutants

Volume 13, Issue 1, Pages (February 2006)

Nutrition and Metabolism of the Surgical Patient, Part II

Genome-Wide SNP Analysis in Cancer: Leukemia Shows the Way

Volume 80, Issue 7, Pages (October 2011)

Linking DNA Damage, NAD+/SIRT1, and Aging

Should Supervision be Required for Early-Career Nurse Practitioners?

Tipping the Energy Balance toward Longevity

Cellular Alchemy and the Golden Age of Reprogramming

Presentation transcript:

Volume 44, Issue 1, Pages 13-23 (February 2017) Prevention of 5-fluorouracil-induced early severe toxicity by pre-therapeutic dihydropyrimidine dehydrogenase deficiency screening: Assessment of a multiparametric approach Michele Boisdron-Celle, Olivier Capitain, Roger Faroux, Christophe Borg, Jean Philippe Metges, Marie Pierre Galais, Mehdi Kaassis, Jaafar Bennouna, Karine Bouhier-Leporrier, Eric Francois, Isabelle Baumgaertner, Véronique Guerin-Meyer, Oana Cojocarasu, Celia Roemer-Becuwe, Claire Stampfli, Ludovic Rosenfeld, Thierry Lecompte, Virginie Berger, Alain Morel, Erick Gamelin Seminars in Oncology Volume 44, Issue 1, Pages 13-23 (February 2017) DOI: 10.1053/j.seminoncol.2017.02.008 Copyright © 2017 Elsevier Inc. Terms and Conditions

Fig. 1 Metabolic pathways of 5-fluorouracil. Seminars in Oncology 2017 44, 13-23DOI: (10.1053/j.seminoncol.2017.02.008) Copyright © 2017 Elsevier Inc. Terms and Conditions

Fig. 2 Distribution of DPD enzyme activity in a healthy population. Distribution of DPD enzyme activity in the 132 caucasian individuals tested in this study. The distribution differs significantly from Gaussian Normal and has significant positive skew and kurtosis [7]. Seminars in Oncology 2017 44, 13-23DOI: (10.1053/j.seminoncol.2017.02.008) Copyright © 2017 Elsevier Inc. Terms and Conditions

Fig. 3 Different SNPs in the hot spots of the DPYD gene. In red are shown the SNPs systematically screened in clinical practice. Seminars in Oncology 2017 44, 13-23DOI: (10.1053/j.seminoncol.2017.02.008) Copyright © 2017 Elsevier Inc. Terms and Conditions

Fig. 4 Study design. Seminars in Oncology 2017 44, 13-23DOI: (10.1053/j.seminoncol.2017.02.008) Copyright © 2017 Elsevier Inc. Terms and Conditions

Fig. 5 Survival probability of the two populations of patients without grade ≥3 toxic events (arm A: blue, arm B: red). Seminars in Oncology 2017 44, 13-23DOI: (10.1053/j.seminoncol.2017.02.008) Copyright © 2017 Elsevier Inc. Terms and Conditions