Assessment of Intraventricular Mechanical Dyssynchrony and Prediction of Response to Cardiac Resynchronization Therapy: Comparison between Tissue Doppler.

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Assessment of Intraventricular Mechanical Dyssynchrony and Prediction of Response to Cardiac Resynchronization Therapy: Comparison between Tissue Doppler Imaging and Real-Time Three-Dimensional Echocardiography Sebastiaan A. Kleijn, MD, Jeroen van Dijk, MD, PhD, Carel C. de Cock, MD, PhD, Cor P. Allaart, MD, PhD, Albert C. van Rossum, MD, PhD, Otto Kamp, MD, PhD Journal of the American Society of Echocardiography Volume 22, Issue 9, Pages 1047-1054 (September 2009) DOI: 10.1016/j.echo.2009.06.012 Copyright © 2009 American Society of Echocardiography Terms and Conditions

Figure 1 Mean ± SD and individual data plot of TDI-SDI (A) and 3D-SDI (B) according to the degree of LVEF. The cutoff value (dotted line) of significant mechanical dyssynchrony for each method. Mean number (in parentheses) of subjects within the subgroup whose data exceed the cutoff value for mechanical dyssynchrony. LVEF, Left ventricular ejection fraction; TDI-SDI, the SD of time to peak systolic tissue velocity of 12 left ventricular myocardial segments; 3D-SDI, the SD of time from QRS onset to minimal volume of 16 LV subvolumes. Journal of the American Society of Echocardiography 2009 22, 1047-1054DOI: (10.1016/j.echo.2009.06.012) Copyright © 2009 American Society of Echocardiography Terms and Conditions

Figure 2 Agreement between TDI and RT3DE on presence or absence of significant mechanical dyssynchrony depending on the (A) severity of LV dysfunction and (B) cause of cardiomyopathy. LVEF, Left ventricular ejection fraction. Journal of the American Society of Echocardiography 2009 22, 1047-1054DOI: (10.1016/j.echo.2009.06.012) Copyright © 2009 American Society of Echocardiography Terms and Conditions

Figure 3 Receiver operating characteristic curve analysis on TDI-SDI and 3D-SDI to predict response to CRT. Diagonal segments are produced by ties. TDI-SDI, The SD of time to peak systolic tissue velocity of 12 left ventricular myocardial segments; 3D-SDI, the SD of time from QRS onset to minimal volume of 16 LV subvolumes. Journal of the American Society of Echocardiography 2009 22, 1047-1054DOI: (10.1016/j.echo.2009.06.012) Copyright © 2009 American Society of Echocardiography Terms and Conditions