Volume 151, Issue 4, Pages 660-669.e4 (October 2016) Prevalence of Sclerosing Cholangitis Detected by Magnetic Resonance Cholangiography in Patients With Long-term Inflammatory Bowel Disease  Aida Kapic Lunder, Johannes Roksund Hov, Arne Borthne, Jostein Gleditsch, Glenn Johannesen, Knut Tveit, Ellen Viktil, Magne Henriksen, Øistein Hovde, Gert Huppertz-Hauss, Ole Høie, Marte Lie Høivik, Iril Monstad, Inger Camilla Solberg, Jørgen Jahnsen, Tom Hemming Karlsen, Bjørn Moum, Morten Vatn, Anne Negård  Gastroenterology  Volume 151, Issue 4, Pages 660-669.e4 (October 2016) DOI: 10.1053/j.gastro.2016.06.021 Copyright © 2016 AGA Institute Terms and Conditions

Figure 1 Flowchart of the study population. LTF, lost to follow-up. Gastroenterology 2016 151, 660-669.e4DOI: (10.1053/j.gastro.2016.06.021) Copyright © 2016 AGA Institute Terms and Conditions

Figure 2 MRC images of the bile duct lesions. (A) Cholangiogram in a 57-year-old male patient with CD and known PSC shows extensive stricturing in the liver hilum (long straight arrow) and marked dilatation in the periphery (arrowheads). (B) Cholangiogram of a 38-year-old male CD patient with known PSC, which was the one false-negative exam in the study, shows hilar and intrahepatic strictures (long straight arrow) at second glance. (C) Stricturing of the common bile duct and intrahepatic ductules (long straight arrow), intrahepatic bile duct dilatation (arrowheads), mural irregularities (short arrow), and beading (curved arrow) in a 53-year-old male UC patient. (D) Stricturing at the confluence of the left bile duct and the common bile duct as well as intrahepatically (long straight arrow) in a 73-year-old female CD patient. The arrowhead points at the dilatation of the peripheral bile ducts in the left liver lobe. (E) Stricturing at the confluence of the left bile duct and the common bile duct (long straight arrow) in a 44-year-old female patient with UC. The arrowheads demonstrate dilatation of the peripheral bile ducts. (F) Stricture (long straight arrow) and dilatation (arrowhead) of right intrahepatic bile ducts in a 43-year-old male CD patient with ileitis only. Gastroenterology 2016 151, 660-669.e4DOI: (10.1053/j.gastro.2016.06.021) Copyright © 2016 AGA Institute Terms and Conditions

Figure 3 MRC flowchart of different PSC subgroups. Gastroenterology 2016 151, 660-669.e4DOI: (10.1053/j.gastro.2016.06.021) Copyright © 2016 AGA Institute Terms and Conditions

Figure 4 Mean liver biochemistry levels during the follow-up period in patients with known PSC (n = 9), new PSC (n = 17), and no PSC (n = 296). (A) Levels of alanine transaminase (ALAT). (B) Levels of alkaline phosphatase (AFOS) at 0, 1, 5, and 10 years. (C) Levels of AFOS at 20 years. The AFOS graphs are split in 2 due to the introduction of a new method for measuring alkaline phosphatase (ALP) in 2003 (ie, between 10 and 20 years follow-up). Reference values before 2003: 70–230 U/L and after 2003: <105 U/L. Gastroenterology 2016 151, 660-669.e4DOI: (10.1053/j.gastro.2016.06.021) Copyright © 2016 AGA Institute Terms and Conditions

Supplementary Figure 1 Four predefined curves depicting different inflammatory bowel disease activity courses.19 Gastroenterology 2016 151, 660-669.e4DOI: (10.1053/j.gastro.2016.06.021) Copyright © 2016 AGA Institute Terms and Conditions