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Copyright © 2015 American Medical Association. All rights reserved. From: Blood Pressure Lowering in Type 2 DiabetesA Systematic Review and Meta-analysis JAMA. 2015;313(6):603-615. doi:10.1001/jama.2014.18574 Figure Legend: Flowchart of Trial Identification for Meta-analysis Date of download: 10/16/2017 Copyright © 2015 American Medical Association. All rights reserved.

Copyright © 2015 American Medical Association. All rights reserved. From: Blood Pressure Lowering in Type 2 DiabetesA Systematic Review and Meta-analysis JAMA. 2015;313(6):603-615. doi:10.1001/jama.2014.18574 Figure Legend: Standardized Associations Between 10–mm Hg Lower Systolic BP and All-Cause Mortality, Macrovascular Outcomes, and Microvascular Outcomes in Diabetic PatientsMacrovascular outcomes include cardiovascular events, coronary heart disease, stroke, and heart failure; and microvascular outcomes include renal failure, retinopathy, and albuminuria. The area of each square is proportional to the inverse variance of the estimate. Horizontal lines indicate 95% CIs of the estimate. BP indicates blood pressure. Date of download: 10/16/2017 Copyright © 2015 American Medical Association. All rights reserved.

Copyright © 2015 American Medical Association. All rights reserved. From: Blood Pressure Lowering in Type 2 DiabetesA Systematic Review and Meta-analysis JAMA. 2015;313(6):603-615. doi:10.1001/jama.2014.18574 Figure Legend: Standardized Associations Between 10–mm Hg Lower Systolic BP and All-Cause Mortality, Macrovascular Outcomes, and Microvascular Outcomes Stratified by Mean Systolic BP of Trial Participants at EntryMacrovascular outcomes include cardiovascular events, coronary heart disease, stroke, and heart failure; and microvascular outcomes include renal failure, retinopathy, and albuminuria. Mean baseline blood pressure (BP) is weighted by number of participants. The area of each square is proportional to the inverse variance of the estimate. Horizontal lines indicate 95% CIs of the estimate. SBP indicates systolic blood pressure. Date of download: 10/16/2017 Copyright © 2015 American Medical Association. All rights reserved.

Copyright © 2015 American Medical Association. All rights reserved. From: Blood Pressure Lowering in Type 2 DiabetesA Systematic Review and Meta-analysis JAMA. 2015;313(6):603-615. doi:10.1001/jama.2014.18574 Figure Legend: Standardized Associations Between 10–mm Hg Lower Systolic BP and All-Cause Mortality, Macrovascular Outcomes, and Microvascular Outcomes, Stratified by Mean Achieved Systolic BP in the Active Group of Each TrialMacrovascular outcomes include cardiovascular events, coronary heart disease, stroke, and heart failure; and microvascular outcomes include renal failure, retinopathy, and albuminuria. The mean achieved blood pressure (BP) is weighted by number of participants. The area of each square is proportional to the inverse variance of the estimate. Horizontal lines indicate 95% CIs of the estimate. SBP indicates systolic blood pressure. Date of download: 10/16/2017 Copyright © 2015 American Medical Association. All rights reserved.

Copyright © 2015 American Medical Association. All rights reserved. From: Blood Pressure Lowering in Type 2 DiabetesA Systematic Review and Meta-analysis JAMA. 2015;313(6):603-615. doi:10.1001/jama.2014.18574 Figure Legend: The area of each square is proportional to the inverse variance of the estimate. Horizontal lines indicate 95% CIs of the estimate. ACE indicates angiotensin-converting enzyme; ARB, angiotensin II receptor blocker; CCB, calcium channel blocker. Date of download: 10/16/2017 Copyright © 2015 American Medical Association. All rights reserved.