Riccardo Vismara, Alberto M

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In vitro assessment of mitral valve function in cyclically pressurized porcine hearts Riccardo Vismara, Alberto M. Leopaldi, Marco Piola, Chiara Asselta, Massimo Lemma, Carlo Antona, Alberto Redaelli, Frans van de Vosse, Marcel Rutten, Gianfranco B. Fiore Medical Engineering and Physics Volume 38, Issue 4, Pages 346-353 (April 2016) DOI: 10.1016/j.medengphy.2016.01.007 Copyright © 2016 IPEM Terms and Conditions

Fig. 1 Left: A photography of the EPML; Right: schematic of the mock loop. PD: pulse duplicator; LV: left ventricle; SIS: systemic input impedance; PR: pre-load. Medical Engineering and Physics 2016 38, 346-353DOI: (10.1016/j.medengphy.2016.01.007) Copyright © 2016 IPEM Terms and Conditions

Fig. 2 Left: A photography of the EPML. Right: Schematic of the mock loop. PP: pulsatile pup; AL: afterload; R: reservoir; CP: centrifugal pump; PL: preload; FFC: Fluid-filled chamber; VP: Vacuum pump; VS: vacuum sealing. Venting for de-airing in the filling procedure. Medical Engineering and Physics 2016 38, 346-353DOI: (10.1016/j.medengphy.2016.01.007) Copyright © 2016 IPEM Terms and Conditions

Fig. 3 Representative flow and pressure curves recorded with the two mock loops. Early systole (ES), peak systole (PS) and late systole (LS) are identified in the flow rate courses. Medical Engineering and Physics 2016 38, 346-353DOI: (10.1016/j.medengphy.2016.01.007) Copyright © 2016 IPEM Terms and Conditions

Fig. 4 Snapshots from the atrial high-speed movie recorded with the IPML (above) and with the EPML, in ES, PS and LS from left to right. Numbers in the images identify the columns of dots used to reconstruct leaflets areas with the Matlab code. Medical Engineering and Physics 2016 38, 346-353DOI: (10.1016/j.medengphy.2016.01.007) Copyright © 2016 IPEM Terms and Conditions

Fig. 5 Available coaptation area (ACA) and coaptation length (CL) in the two mock loops. Medical Engineering and Physics 2016 38, 346-353DOI: (10.1016/j.medengphy.2016.01.007) Copyright © 2016 IPEM Terms and Conditions

Fig. 6 PMs-MV distances in the two mock loops. Medical Engineering and Physics 2016 38, 346-353DOI: (10.1016/j.medengphy.2016.01.007) Copyright © 2016 IPEM Terms and Conditions

Fig. 7 Schematics of left ventricle configurations showing relative positioning of mitral valve plane and papillary muscles in physiologic conditions (A), in the EPML (B), in the IPML (C). Medical Engineering and Physics 2016 38, 346-353DOI: (10.1016/j.medengphy.2016.01.007) Copyright © 2016 IPEM Terms and Conditions