Volume 357, Issue 9262, Pages (April 2001)

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Presentation transcript:

Volume 357, Issue 9262, Pages 1069-1075 (April 2001) Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study Françoise Imbert-Bismut, PhD, Vlad Ratziu, MD, Laurence Pieroni, PhD, Frederic Charlotte, MD, Yves Benhamou, MD, Prof Thierry Poynard, MD The Lancet Volume 357, Issue 9262, Pages 1069-1075 (April 2001) DOI: 10.1016/S0140-6736(00)04258-6 Copyright © 2001 Elsevier Ltd Terms and Conditions

Figure 1 Study design Independent markers were identified during the first year and their predictive values validated during the second period. HCV=hepatitis C virus. The Lancet 2001 357, 1069-1075DOI: (10.1016/S0140-6736(00)04258-6) Copyright © 2001 Elsevier Ltd Terms and Conditions

Figure 2 ROC curves of fibrosis indices combining five, six, or ten biochemical factors, and age and sex ROC=receiver-operating characteristic. The Lancet 2001 357, 1069-1075DOI: (10.1016/S0140-6736(00)04258-6) Copyright © 2001 Elsevier Ltd Terms and Conditions

Figure 3 Fibrosis index score for each fibrosis stage A:6-marker index: F0 n=56; F1 n=145; F2 n=68; F3 n=28; F4 n=42. B:5-marker index: F0 n=55; F1 n=139; F2 n=64; F3 n=26; F4 n=41. The top and bottom of the box are the 25th and 75th percenties. The length of the box is thus IQR. The line through the middle of the box is the median. The upper error bar is the largest observation ⩽75th percentile plus 1·5XIQR. The lower error bar is the smallest observation that is ⩾25th percentile minus 1·5×IQR. Bonferroni all-pairwise multiple comparison; p<0·0001 between all stages. The Lancet 2001 357, 1069-1075DOI: (10.1016/S0140-6736(00)04258-6) Copyright © 2001 Elsevier Ltd Terms and Conditions

Figure 4 Relation between fibrosis stage and α2 macroglobulin, haptoglobin, hepatocyte growth factor, and tumour growth factor β1 The Lancet 2001 357, 1069-1075DOI: (10.1016/S0140-6736(00)04258-6) Copyright © 2001 Elsevier Ltd Terms and Conditions