Hydrocortisone and fludrocortisone for prevention of hospital-acquired pneumonia in patients with severe traumatic brain injury (Corti-TC): a double-blind,

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Hydrocortisone and fludrocortisone for prevention of hospital-acquired pneumonia in patients with severe traumatic brain injury (Corti-TC): a double-blind, multicentre phase 3, randomised placebo-controlled trial Dr Karim Asehnoune, MD, Philippe Seguin, MD, Jeremy Allary, MD, Fanny Feuillet, MSc, Sigismond Lasocki, MD, Fabrice Cook, MD, Hervé Floch, MD, Russell Chabanne, MD, Thomas Geeraerts, MD, Claire Roger, MD, Pierre F Perrigault, MD, Jean L Hanouz, MD, Anne C Lukaszewicz, MD, Matthieu Biais, MD, Perrine Boucheix, MD, Claire Dahyot-Fizelier, MD, Xavier Capdevila, MD, Pierre J Mahe, MD, Pascale Le Maguet, MD, Catherine Paugam-Burtz, MD, Soizic Gergaud, MD, Benoit Plaud, MD, Jean M Constantin, MD, Yannick Malledant, MD, Laurent Flet, PharmD, Véronique Sebille, PhD, Antoine Roquilly, MD The Lancet Respiratory Medicine Volume 2, Issue 9, Pages 706-716 (September 2014) DOI: 10.1016/S2213-2600(14)70144-4 Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile The Lancet Respiratory Medicine 2014 2, 706-716DOI: (10.1016/S2213-2600(14)70144-4) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 2 Cumulative incidence of hospital-acquired pneumonia For the entire population (A), patients with adrenal insufficiency (B), and patients with normal adrenal function (C). The Lancet Respiratory Medicine 2014 2, 706-716DOI: (10.1016/S2213-2600(14)70144-4) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 3 Effect of hydrocortisone and fludrocortisone on hospital-acquired pneumonia by subgroup Basal blood cortisol concentration was available for 326 (99%) patients (corticotropin test was not done for two patients in the steroid group) and change in blood cortisol concentration was available for 325 (99%) patients (no corticotropin test for two patients, and change at 60 min not assessed for one patient in the steroid group). MGAP=mechanism, Glasgow coma scale, age, and pressure. The Lancet Respiratory Medicine 2014 2, 706-716DOI: (10.1016/S2213-2600(14)70144-4) Copyright © 2014 Elsevier Ltd Terms and Conditions