Volume 18, Issue 10, Pages (October 2017)

Slides:

Advertisements

Similar presentations

Crohn's disease Prof Daniel C Baumgart, MD, Prof William J Sandborn, MD The Lancet Volume 380, Issue 9853, Pages (November 2012) DOI: /S (12)

Advertisements

Fever of unknown origin and cancer: a population-based study

Volume 14, Issue 12, Pages (November 2013)

Volume 12, Issue 9, Pages (September 2011)

Volume 16, Issue 2, Pages (February 2015)

Volume 12, Issue 11, Pages (October 2011)

Volume 376, Issue 9747, Pages (October 2010)

Volume 18, Issue 7, Pages (July 2017)

Outcome for Patients with Malignant Pleural Mesothelioma Referred for Trimodality Therapy in Western Australia Arman Hasani, MBBS, FRACP, John M. Alvarez,

Volume 16, Issue 9, Pages (September 2015)

Volume 5, Issue 4, Pages (April 2006)

Volume 13, Issue 12, Pages (December 2012)

Volume 389, Issue 10076, Pages (April 2017)

Evaluation of early administration of simvastatin in the prevention and treatment of delirium in critically ill patients undergoing mechanical ventilation.

Volume 9, Issue 5, Pages (May 2008)

Volume 366, Issue 9499, Pages (November 2005)

The Role of Radiation Therapy in Malignant Thymoma: A Surveillance, Epidemiology, and End Results Database Analysis Annemarie T. Fernandes, BA, Eric.

Phase I Trial of Cediranib in Combination with Cisplatin and Pemetrexed in Chemonaive Patients with Unresectable Malignant Pleural Mesothelioma (SWOG.

Volume 15, Issue 4, Pages (April 2014)

Volume 373, Issue 9663, Pages (February 2009)

Susan C. Scott, MD, Nathan A. Pennell, MD, PhD

Megan B. Barnet, BS, M. B. B. S. , Sandra O’Toole, PhD, Lisa G

Volume 2, Issue 6, Pages (June 2015)

A Phase II Study of PF in Patients with Advanced Malignant Pleural Mesothelioma. CCTG Trial IND.207 Paul Wheatley-Price, MBChB, MD, Quincy Chu,

Volume 14, Issue 8, Pages (July 2013)

Volume 18, Issue 7, Pages (July 2017)

Volume 14, Issue 8, Pages (July 2013)

John E. Pilling, FRCS (CTh), Michael E

Paediatric mortality related to pandemic influenza A H1N1 infection in England: an observational population-based study Nabihah Sachedina, MBBS, Prof.

Tumor Suppressor microRNAs Contribute to the Regulation of PD-L1 Expression in Malignant Pleural Mesothelioma Steven C. Kao, PhD, Yuen Yee Cheng, PhD,

Volume 15, Issue 1, Pages (January 2014)

Inhibition of EGFR, HER2, and HER3 signalling in patients with colorectal cancer wild- type for BRAF, PIK3CA, KRAS, and NRAS (FOCUS4-D): a phase 2–3 randomised.

Volume 13, Issue 12, Pages (December 2012)

Volume 14, Issue 6, Pages (May 2013)

Phase II Randomized Study of Two Regimens of Sequentially Administered Mitomycin C and Irinotecan in Patients with Unresectable Esophageal and Gastroesophageal.

Volume 14, Issue 11, Pages (October 2013)

Impact of Positive Nodal Metastases in Patients with Thymic Carcinoma and Thymic Neuroendocrine Tumors Benny Weksler, MD, Anthony Holden, MD, Jennifer.

Volume 18, Issue 3, Pages (March 2017)

Volume 385, Issue 9962, Pages (January 2015)

Sorafenib in combination with transarterial chemoembolisation in patients with unresectable hepatocellular carcinoma (TACE 2): a randomised placebo-controlled,

Volume 15, Issue 8, Pages (July 2014)

Ellen Kim, MD, MPH, Siran Koroukian, PhD, Charles R. Thomas, MD

Comparison of Four PD-L1 Immunohistochemical Assays in Lung Cancer

Volume 9, Issue 4, Pages (April 2008)

Volume 13, Issue 11, Pages (November 2012)

Volume 5, Issue 4, Pages (April 2018)

Phase-I/II Study of Bortezomib in Combination with Carboplatin and Bevacizumab as First-Line Therapy in Patients With Advanced Non–Small-Cell Lung Cancer

Volume 14, Issue 8, Pages (July 2013)

Volume 373, Issue 9658, Pages (January 2009)

Volume 375, Issue 9714, Pages (February 2010)

Volume 15, Issue 8, Pages (July 2014)

Josine Quispel-Janssen, MD, Vincent van der Noort, PhD, Jeltje F

Outcome and Biomarker Analysis from a Multicenter Phase 2 Study of Ipilimumab in Combination with Carboplatin and Etoposide as First-Line Therapy for.

Volume 371, Issue 9618, Pages (March 2008)

Is Radiotherapy Useful for Treating Pain in Mesothelioma

Volume 18, Issue 10, Pages (October 2017)

Volume 375, Issue 9715, Pages (February 2010)

Volume 376, Issue 9747, Pages (October 2010)

Volume 372, Issue 9632, Pages (July 2008)

Pulmonary Resection for Metastases from Colorectal Cancer

Ethnic Differences in the Management of Lung Cancer in New Zealand

A Pathological Complete Response in Malignant Pleural Mesothelioma after Combination Chemotherapy with Carboplatin and Pemetrexed Steven Chuan-Hao Kao,

SWOG S0709: Randomized Phase II Trial of Erlotinib versus Erlotinib Plus Carboplatin/Paclitaxel in Patients with Advanced Non–Small Cell Lung Cancer and.

David James Pinato, MD, MRes, Francesco A

Volume 14, Issue 7, Pages (June 2013)

Brief Report: A Phase II Study of Sunitinib in Malignant Pleural Mesothelioma. The NCIC Clinical Trials Group Scott A. Laurie, MD, FRCPC, Ashish Gupta,

Volume 390, Issue 10107, Pages (November 2017)

Effect of strikes by health workers on mortality between 2010 and 2016 in Kilifi, Kenya: a population-based cohort analysis Gerald Ong'ayo, MBChB, Michael.

Debby P. M. van den Bogaert, MD, Ellen M

Volume 20, Issue 8, Pages (August 2019)

Presentation transcript:

Volume 18, Issue 10, Pages 1386-1396 (October 2017) Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study Prof Nico van Zandwijk, MD, Nick Pavlakis, PhD, Steven C Kao, MBChB, Anthony Linton, PhD, Prof Michael J Boyer, MBBS, Prof Stephen Clarke, PhD, Yennie Huynh, BSc, Agata Chrzanowska, MSc, Prof Michael J Fulham, MBBS, Prof Dale L Bailey, PhD, Wendy A Cooper, PhD, Prof Leonard Kritharides, PhD, Lloyd Ridley, MBBS, Scott T Pattison, MSc, Jennifer MacDiarmid, PhD, Himanshu Brahmbhatt, PhD, Glen Reid, PhD The Lancet Oncology Volume 18, Issue 10, Pages 1386-1396 (October 2017) DOI: 10.1016/S1470-2045(17)30621-6 Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 1 Trial flow diagram The Lancet Oncology 2017 18, 1386-1396DOI: (10.1016/S1470-2045(17)30621-6) Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 2 Swimmer plot of time on study treatment, response status, and survival (A); and waterfall plot of pleural CT and PET–CT findings (B) In (B), CT findings are presented for 22 patients according to modified Response Evaluation Criteria in Solid Tumors. PET–CT findings show the mean percentage change in maximum standardised uptake value from five pleural regions of interest in the affected hemithorax after one cycle of treatment (appendix). *Patient four got a second primary cancer diagnosis at 7 weeks. The Lancet Oncology 2017 18, 1386-1396DOI: (10.1016/S1470-2045(17)30621-6) Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 3 Kaplan-Meier graph of overall survival (all-cause mortality) n=26. 21 deaths were recorded. The Lancet Oncology 2017 18, 1386-1396DOI: (10.1016/S1470-2045(17)30621-6) Copyright © 2017 Elsevier Ltd Terms and Conditions