Raltegravir for the treatment of patients co-infected with HIV and tuberculosis (ANRS 12 180 Reflate TB): a multicentre, phase 2, non-comparative, open-label,

Slides:



Advertisements
Similar presentations
A randomized trial to estimate efficacy and safety of 2 doses of raltegravir and efavirenz for treatment of HIV-TB co-infected patients : ANRS REFLATE.
Advertisements

Crohn's disease Prof Daniel C Baumgart, MD, Prof William J Sandborn, MD The Lancet Volume 380, Issue 9853, Pages (November 2012) DOI: /S (12)
Volume 14, Issue 4, Pages (April 2013)
Towards universal access to HIV prevention, treatment, care, and support: the role of tuberculosis/HIV collaboration  Alasdair Reid, MD, Fabio Scano,
Enhanced performance feedback and patient participation to improve hand hygiene compliance of health-care workers in the setting of established multimodal.
Volume 379, Issue 9824, Pages (April 2012)
Volume 357, Issue 9273, Pages (June 2001)
BMI and risk of dementia in two million people over two decades: a retrospective cohort study  Dr Nawab Qizilbash, MRCP, John Gregson, PhD, Michelle E.
Volume 367, Issue 9517, Pages (April 2006)
Surgery versus conservative management for recurrent and ongoing left-sided diverticulitis (DIRECT trial): an open-label, multicentre, randomised controlled.
Volume 357, Issue 9257, Pages (March 2001)
Volume 359, Issue 9322, Pages (June 2002)
Pharmacogenetics and future drug development and delivery
Volume 11, Issue 4, Pages (April 2012)
Urine antigen test for diagnosis of HIV-associated tuberculosis
Volume 376, Issue 9734, Pages (July 2010)
Long-term effects of hormone replacement therapy
Intravenous or nebulised magnesium sulphate versus standard therapy for severe acute asthma (3Mg trial): a double-blind, randomised controlled trial 
Volume 14, Issue 4, Pages (April 2013)
Volume 373, Issue 9666, Pages (March 2009)
Infections related to totally implantable venous-access ports
Volume 371, Issue 9611, Pages (February 2008)
Volume 376, Issue 9734, Pages (July 2010)
Volume 366, Issue 9482, Pages (July 2005)
Volume 13, Issue 3, Pages (March 2012)
Volume 379, Issue 9823, Pages (April 2012)
Long-term effects of hormone replacement therapy
Volume 366, Issue 9486, Pages (August 2005)
Characteristics and survival of patients with Ebola virus infection, malaria, or both in Sierra Leone: a retrospective cohort study  Matthew Waxman, MD,
Volume 366, Issue 9482, Pages (July 2005)
Trends in virological and clinical outcomes in individuals with HIV-1 infection and virological failure of drugs from three antiretroviral drug classes:
Surgery versus conservative management for recurrent and ongoing left-sided diverticulitis (DIRECT trial): an open-label, multicentre, randomised controlled.
Volume 372, Issue 9642, Pages (September 2008)
Differences in outcome according to Clostridium difficile testing method: a prospective multicentre diagnostic validation study of C difficile infection 
Volume 2, Issue 6, Pages (June 2015)
Effect of 3 years of biannual mass drug administration with albendazole on lymphatic filariasis and soil-transmitted helminth infections: a community-based.
Volume 9, Issue 10, Pages (October 2008)
Screening of immigrants in the UK for imported latent tuberculosis: a multicentre cohort study and cost-effectiveness analysis  Manish Pareek, MRCP, John.
Safety and immunogenicity of a parenteral P2-VP8-P[8] subunit rotavirus vaccine in toddlers and infants in South Africa: a randomised, double-blind, placebo-controlled.
Group B streptococcus vaccination in pregnant women with or without HIV in Africa: a non-randomised phase 2, open-label, multicentre trial  Prof Robert.
Volume 375, Issue 9732, Pages (June 2010)
Prevalence of tuberculosis, hepatitis C virus, and HIV in homeless people: a systematic review and meta-analysis  Ulla Beijer, PhD, Achim Wolf, MSc, Dr.
Volume 4, Issue 6, Pages (June 2017)
Volume 379, Issue 9821, Pages (March 2012)
Volume 15, Issue 1, Pages (January 2014)
The effect of socioeconomic deprivation on the association between an extended measurement of unhealthy lifestyle factors and health outcomes: a prospective.
Tadalafil in patients with chronic obstructive pulmonary disease: a randomised, double- blind, parallel-group, placebo-controlled trial  Dr Andrew R Goudie,
Volume 6, Issue 6, Pages (June 2005)
Volume 393, Issue 10171, Pages (February 2019)
Safety, pharmacokinetics, and immunogenicity of a co-formulated cocktail of three human monoclonal antibodies targeting Ebola virus glycoprotein in healthy.
Volume 12, Issue 8, Pages (August 2013)
Volume 372, Issue 9647, Pages (October 2008)
Volume 2, Issue 6, Pages e243-e251 (June 2015)
Intravenous or nebulised magnesium sulphate versus standard therapy for severe acute asthma (3Mg trial): a double-blind, randomised controlled trial 
Volume 371, Issue 9627, Pages (May 2008)
Urine antigen test for diagnosis of HIV-associated tuberculosis
Primary prophylaxis of cryptococcal disease with fluconazole in HIV-positive Ugandan adults: a double-blind, randomised, placebo-controlled trial  Dr.
Department of Error The Lancet Volume 369, Issue 9564, (March 2007)
Volume 375, Issue 9714, Pages (February 2010)
Volume 361, Issue 9352, Pages (January 2003)
Effect of standard dose paracetamol versus placebo as antipyretic therapy on liver injury in adult dengue infection: a multicentre randomised controlled.
Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial  Dr David Preiss, PhD, Suzanne M Lloyd,
Efficacy and safety of tribendimidine against Opisthorchis viverrini: two randomised, parallel-group, single-blind, dose-ranging, phase 2 trials  Somphou.
Infections related to totally implantable venous-access ports
Volume 393, Issue 10177, Pages (March 2019)
Volume 385, Issue 9985, Pages (June 2015)
Volume 14, Issue 7, Pages (June 2013)
Clinic attendance and disengagement of young adults with type 1 diabetes after transition of care from paediatric to adult services (TrACeD): a randomised,
Volume 371, Issue 9611, Pages (February 2008)
Volume 18, Issue 6, Pages (June 2019)
Presentation transcript:

Raltegravir for the treatment of patients co-infected with HIV and tuberculosis (ANRS 12 180 Reflate TB): a multicentre, phase 2, non-comparative, open-label, randomised trial  Prof Beatriz Grinsztejn, PhD, Nathalie De Castro, MD, Vincent Arnold, PhD, Prof Valdiléa G Veloso, PhD, Prof Mariza Morgado, PhD, José Henrique Pilotto, PhD, Prof Carlos Brites, PhD, José Valdez Madruga, MSc, Nêmora Tregnago Barcellos, PhD, Breno Riegel Santos, MD, Carla Vorsatz, MD, Catherine Fagard, MD, Marilia Santini-Oliveira, PhD, Olivier Patey, MD, Constance Delaugerre, PhD, Prof Geneviève Chêne, PhD, Prof Jean-Michel Molina, MD  The Lancet Infectious Diseases  Volume 14, Issue 6, Pages 459-467 (June 2014) DOI: 10.1016/S1473-3099(14)70711-X Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile The Lancet Infectious Diseases 2014 14, 459-467DOI: (10.1016/S1473-3099(14)70711-X) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 2 Virological response Error bars are 95% CIs. The Lancet Infectious Diseases 2014 14, 459-467DOI: (10.1016/S1473-3099(14)70711-X) Copyright © 2014 Elsevier Ltd Terms and Conditions