Decrease of Prefrontal Metabolism After Subthalamic Stimulation in Obsessive- Compulsive Disorder: A Positron Emission Tomography Study Florence Le Jeune,

Slides:

Advertisements

Similar presentations

Stimulated Gene Expression Profiles as a Blood Marker of Major Depressive Disorder Sabine Spijker, Jeroen S. Van Zanten, Simone De Jong, Brenda W.J.H.

Advertisements

Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial Peter Nagele, Andreas Duma, Michael Kopec, Marie Anne Gebara, Alireza.

Date of download: 6/21/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Neural and Genetic Correlates of Antidepressant Response.

Date of download: 6/27/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Neural Correlates of Antinociception in Borderline.

Date of download: 7/2/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Brain Serotonin and Dopamine Transporter Bindings.

Date of download: 7/6/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Disrupted Ventromedial Prefrontal Function, Alcohol.

Date of download: 7/9/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Meta-analysis of Functional Magnetic Resonance Imaging.

Apomorphine pump in advanced Parkinson's disease: Effects on motor and nonmotor symptoms with brain metabolism correlations Manon Auffret, Florence Le.

Laurent Juillard, MD, PhD, Marc F

Neural Correlates of Impaired Cognitive Control over Working Memory in Schizophrenia Teal S. Eich, Derek Evan Nee, Catherine Insel, Chara Malapani, Edward.

Neurophysiological correlates of metabolic syndrome and cognitive impairment in schizophrenia: A structural equation modeling approach Laurent Boyer,

Copyright © 2013 American Medical Association. All rights reserved.

Dardo Tomasi, Nora D. Volkow Biological Psychiatry

Functional Magnetic Resonance Imaging During Planning Before and After Cognitive- Behavioral Therapy in Pediatric Obsessive-Compulsive Disorder Chaim.

Ellemarije Altena, Hugo Vrenken, Ysbrand D. Van Der Werf, Odile A

A Randomized, Placebo-Controlled Trial of OROS Methylphenidate in Adults with Attention-Deficit/Hyperactivity Disorder Joseph Biederman, Eric Mick, Craig.

Gray Matter Alterations in Adults with Attention-Deficit/Hyperactivity Disorder Identified by Voxel Based Morphometry Larry J. Seidman, Joseph Biederman,

Aggregatibacter aphrophilus brain abscess secondary to primary tooth extraction: Case report and literature review Sofia Maraki, Ioannis S. Papadakis,

Volume 16, Issue 8, Pages (August 2017)

JAMA Psychiatry. 2014;71(8): doi: /jamapsychiatry Figure Legend:

Reduced Neuronal Activity in Language-Related Regions After Transcranial Magnetic Stimulation Therapy for Auditory Verbal Hallucinations Jochen Kindler,

Deep Brain Stimulation: Current and Future Clinical Applications

Quantitative Magnetization Transfer Imaging as a Biomarker for Effects of Systemic Inflammation on the Brain Neil A. Harrison, Ella Cooper, Nicholas.

Topiramate for the Treatment of Binge Eating Disorder Associated With Obesity: A Placebo-Controlled Study Susan L. McElroy, James I. Hudson, Julie A.

Copyright © 2012 American Medical Association. All rights reserved.

Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography.

Limbic versus cognitive target for deep brain stimulation in treatment-resistant depression: Accumbens more promising than caudate Bruno Millet, Nematollah.

Volume 21, Issue 4, Pages xv-xxiii (December 1998)

Scared to the Marrow: Pitfalls and Pearls in Renal Imaging

Hironori Yoshida, MD, Young Hak Kim, MD Journal of Thoracic Oncology

Keith A. Josephs, MD, MST, MSc Mayo Clinic Proceedings

Motor and Nonmotor Circuitry Activation Induced by Subthalamic Nucleus Deep Brain Stimulation in Patients With Parkinson Disease Emily J. Knight, PhD,

Communicative Signaling Activates ‘Broca's’ Homolog in Chimpanzees

Dyspnea-Related Cues Engage the Prefrontal Cortex

Sequential effects of propofol on functional brain activation induced by auditory language processing: an event-related functional magnetic resonance.

Volume 128, Issue 7, Pages (June 2005)

Deep Brain Stimulation for Treatment-Resistant Depression

Michael Ewers, Reisa A. Sperling, William E. Klunk, Michael W

Deep Brain Stimulation: Current and Future Clinical Applications

Shigeru Saito, MD, So-kichi Tanaka, MD

Left middle frontal cortex, caudate nuclei

Network hubs in the human brain

Refractory hyponatremia

Hironori Yoshida, MD, Young Hak Kim, MD Journal of Thoracic Oncology

Apathy and depression: Which clinical specificities?

Whole body [18F]fluorodeoxyglucose positron emission tomography imaging for the diagnosis of pacemaker or implantable cardioverter defibrillator infection:

Can We Share a Pain We Never Felt

Volume 17, Issue 2, Pages (August 1996)

Susannah J. Tye, PhD, Mark A. Frye, MD, Kendall H. Lee, MD, PhD

Volume 1, Issue 4, Pages (September 2014)

Intramedullary Reactive Fibrosis as Mimic of Prostate Cancer Bone Metastasis on 11C- Choline Positron Emission and Computed Tomography Tyler Trump, BS,

Changes of Brain Magnetic Resonance Imaging Findings After Congenital Aortic Arch Anomaly Repair Using Regional Cerebral Perfusion in Neonates and Young.

Enhanced neuroactivation during verbal memory processing in postmenopausal women receiving short-term hormone therapy Carol C. Persad, Ph.D., Jon-Kar.

Salvage Operation in Case of Oligometastatic Disease

Caroline H. Siegel, MD, Richard S. Finn, MD, Michael G. Ho, MD

Neural Primacy of the Salience Processing System in Schizophrenia

Ineffectiveness of Crizotinib on Brain Metastases in Two Cases of Lung Adenocarcinoma with EML4-ALK Rearrangement Denis Maillet, MD, Isabelle Martel-Lafay,

Central pontine myelinolysis

Activation of Heschl’s Gyrus during Auditory Hallucinations

Positron emission tomography study of regional cerebral blood flow and flow– metabolism coupling during general anaesthesia with xenon in humans† S.

The Neural Bases of Cognitive Conflict and Control in Moral Judgment

Volume 57, Issue 6, Pages (June 2000)

Sharon L. Thompson-Schill, Mark D'Esposito, Irene P. Kan Neuron

Volume 128, Issue 3, Pages (March 2005)

Clinical Concepts Emerging from fMRI Functional Connectomics

Volume 120, Issue 2, Pages (February 2001)

Functional-Anatomic Correlates of Individual Differences in Memory

Recurrent Myasthenia Gravis Due to a Pleural Implant 3 Years After Radical Thymectomy Stijn R.G. Heyman, MD, Hendrik De Raeve, MD, PhD, Rudy Mercelis,

Volume 72, Issue 12, (December 2007)

DMN changes in patients with HE

Presentation transcript:

Decrease of Prefrontal Metabolism After Subthalamic Stimulation in Obsessive- Compulsive Disorder: A Positron Emission Tomography Study Florence Le Jeune, Marc Vérin, Karim N'Diaye, Dominique Drapier, Emmanuelle Leray, Sophie Tezenas Du Montcel, Nicolas Baup, Antoine Pelissolo, Mircea Polosan, Luc Mallet, Jérome Yelnik, Bertrand Devaux, Denys Fontaine, Isabelle Chereau, Aurélie Bourguignon, Julie Peron, Paul Sauleau, Sylvie Raoul, Etienne Garin, Marie-Odile Krebs, Nematollah Jaafari, Bruno Millet Biological Psychiatry Volume 68, Issue 11, Pages 1016-1022 (December 2010) DOI: 10.1016/j.biopsych.2010.06.033 Copyright © 2010 Society of Biological Psychiatry Terms and Conditions

Figure 1 Design of positron emission tomography analysis in patients suffering from severe obsessive-compulsive disorder treated by subthalamic nucleus deep brain stimulation. CE, clinical evaluation; D, day; M, month. Biological Psychiatry 2010 68, 1016-1022DOI: (10.1016/j.biopsych.2010.06.033) Copyright © 2010 Society of Biological Psychiatry Terms and Conditions

Figure 2 Significant increase in glucose metabolism in the right frontal middle gyrus (Brodmann's area 10) in Off-Stimulation obsessive-compulsive disorder patients compared with healthy control subjects (p < .005). Coronal views projected onto brain slices of a standard magnetic resonance imaging (x,y,z Talairach coordinates). Biological Psychiatry 2010 68, 1016-1022DOI: (10.1016/j.biopsych.2010.06.033) Copyright © 2010 Society of Biological Psychiatry Terms and Conditions

Figure 3 Significant decrease in glucose metabolism in On-Stimulation compared with Off-Stimulation in the cingulate gyrus (Brodmann's area 24 and 32) and left frontal lobe (medial gyrus Brodmann's area 6) (p < .005). Transversal, sagittal, and coronal views projected onto brain slices of a standard magnetic resonance imaging (x,y,z Talairach coordinates). Biological Psychiatry 2010 68, 1016-1022DOI: (10.1016/j.biopsych.2010.06.033) Copyright © 2010 Society of Biological Psychiatry Terms and Conditions

Figure 4 Correlation between metabolic change induced by stimulation and concomitant clinical improvement. Whole-brain analysis shows a significant cluster of correlation in the ventromedial prefrontal cortex with the decrease in the Yale–Brown Obsessive Compulsive Scale score. Biological Psychiatry 2010 68, 1016-1022DOI: (10.1016/j.biopsych.2010.06.033) Copyright © 2010 Society of Biological Psychiatry Terms and Conditions