Applied Bioinformatics & Chemoinformatics: Techniques, Tools and Opportunities. FATOKI, Toluwase H. Department of Biochemistry, Federal University of Technology, Akure, Nigeria. +2347032219821 hezekiahfatoki@gmail.com www.linkedin.com/in/hezekiahfatoki www.fheztbioinformatics.wordpress.com

“None of us is as smart as all of us” – Ken Blanchard. “If you want to go fast, go alone. If you want to go far, go together.” – African Proverb.

OUTLINES Introduction to Genetic Engineering Sequencing: The Next Generation Introduction to Bioinformatics Overview of Bioinformatics in Africa Essential Bioinformatics Introduction to Database and Tools Introduction to Chemoinformatics/Pharmacoinformatics Applications of Bioinformatics Application in Biotechnology Industries Application in Biomedical and Biopharmaceuticals Industries Current Trends and Opportunities Questions and Answers

Introduction to Genetic Engineering The Central Dogma Concept Maps of Genetic Engineering

Sequencing: The Next Generation A Life Decoded is the story of this singular milestone in our history, told by the man who through a combination of vision, tenacity, ingenuity, and insight challenged conventional wisdom and refuted his critics to reveal the human genetic code. Desmond S. T. Nicholl, (2008). An Introduction to Genetic Engineering. Cambridge University Press, New York.

Introduction to Bioinformatics

Overview of Bioinformatics in Africa

Desmond S. T. Nicholl, (2008). An Introduction to Genetic Engineering Desmond S. T. Nicholl, (2008). An Introduction to Genetic Engineering. Cambridge University Press, New York.

Medha Bhagwat, PhD. NIH Library Bioinformatics Support Program

Essential Bioinformatics Section I: Introduction And Biological Databases Section II: Sequence Alignment Section III: Gene And Promoter Prediction Section IV: Molecular Phylogenetics Section V: Structural Bioinformatics Section VI: Genomics and Proteomics Arthur M. Lesk,(2002). Introduction to Bioinformatics, Oxford University Press, New York

Introduction to Databases and Tools http://www.cbs.dtu.dk/biotools/ http://molbiol-tools.ca/molecular_biology_freeware.htm http://www.hpc.cam.ac.uk/compbio/software http://bioinformaticssoftwareandtools.co.in/bio_tools.php http://www.bioafrica.net/software.php

NCBI: The National Center for Biotechnology Information (USA): http://ncbi.nlm.nih.gov EBI:The European Bioinformatics Institute: www.ebi.ac.uk SIB:The Swiss Institute of Bioinformatics Expasy (Expert Protein analysis system): www.expasy.org Canadian Bioinformatics Resource http://cbr-rbc.nrc-cnrc.gc.ca/

Chemoinformatics/Pharmacoinformatics The computational methods for in silico drug discovery have been broadly categories into two fields bioinformatics and chemoinformatics. In case of bioinformatics, major emphasis is on identification and validation of drug targets, mainly based on functional/structural annotation of genomes. In case of cheminformatics or pharmacoinformatics, major emphasis is on designing of drug molecules or ligands and their interaction with drug targets. Frank K. Brown (1998) defined Chemoinformatics as the mixing of information resources to transform data into information, and information into knowledge, for the intended purpose of making better decisions faster in the arena of drug lead identification and optimization. https://fheztbioinformatics.wordpress.com/2017/02/04/bioinformatics-chemoinformatics-and-drug-discovery/ Darren Green, (2016). Computational Drug discovery.

APPLICATIONS OF BIOINFORMATICS

Application in Biotechnology Industries Desmond S. T. Nicholl, (2008). An Introduction to Genetic Engineering. Cambridge University Press, New York.

Application in Biomedical and Biopharmaceuticals Industries Desmond S. T. Nicholl, (2008). An Introduction to Genetic Engineering. Cambridge University Press, New York.

Jurgen Drews (2000). Drug Discovery: A Historical Perspective, Science/Drug Discovery, vol.287, 1960-1964.

Current Trends and Opportunities

Thanks for listening Jobs, PhDs and Networks http://blog.biogem.org/2013/03/bioinformatics-carrer-opportunities.html http://www.sib.swiss/about-us/careers http://www.nature.com/naturejobs/science/jobs?q=bioinformatics http://www.bioinformatics.org/jobs/ http://www.linkedin.com/topic/bioinformatics http://www.linkedin.com/topic/computational-biology Online Courses https://www.futurelearn.com https://www.coursera.org Thanks for listening