Volume 70, Issue 4, Pages (October 2008)

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Volume 70, Issue 4, Pages 344-351 (October 2008) Lamotrigine attenuates cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits Hakan Seçkin, MD, PhD, Kazim Yigitkanli, MD, Omer Besalti, PhD, Kemal Kosemehmetoglu, MD, Evrim Ozturk, MD, Serkan Simsek, MD, Deniz Belen, MD, Murad Bavbek, MD Surgical Neurology Volume 70, Issue 4, Pages 344-351 (October 2008) DOI: 10.1016/j.surneu.2007.07.052 Copyright © 2008 Elsevier Inc. Terms and Conditions

Fig. 1 Graph showing the mean heart rates of different groups. HR indicates heart rate; LMT, lamotrigine. Surgical Neurology 2008 70, 344-351DOI: (10.1016/j.surneu.2007.07.052) Copyright © 2008 Elsevier Inc. Terms and Conditions

Fig. 2 Graph showing the mean arterial blood pressures of different groups MABP indicates mean arterial blood pressure. Surgical Neurology 2008 70, 344-351DOI: (10.1016/j.surneu.2007.07.052) Copyright © 2008 Elsevier Inc. Terms and Conditions

Fig. 3 A-E: Photomicrographs of representative cross-sections of the basilar artery corresponding to group 3 (SAH + LTG, 20 mg/kg). Surgical Neurology 2008 70, 344-351DOI: (10.1016/j.surneu.2007.07.052) Copyright © 2008 Elsevier Inc. Terms and Conditions

Fig. 4 Photomicrographs showing basilar artery diameters and cross-sectional areas in different groups. A: Control; B: SAH; C: SAH + LTG. Surgical Neurology 2008 70, 344-351DOI: (10.1016/j.surneu.2007.07.052) Copyright © 2008 Elsevier Inc. Terms and Conditions

Fig. 7 Graph showing the radial wall thickness measurements in 3 different groups. Surgical Neurology 2008 70, 344-351DOI: (10.1016/j.surneu.2007.07.052) Copyright © 2008 Elsevier Inc. Terms and Conditions

Fig. 6 Graph showing the arterial luminal area measurements in 3 different groups. Surgical Neurology 2008 70, 344-351DOI: (10.1016/j.surneu.2007.07.052) Copyright © 2008 Elsevier Inc. Terms and Conditions

Fig. 5 Photomicrographs showing hippocampal slices used to assess neural degeneration. A: Normal appearance—there is no degenerated neuron in dentate gyrus (H&E, ×100). B: Minimal degeneration—scattered degenerated neurons with hyperchromasia and nuclear picnosis are noticed in dentate gyrus (H&E, ×100). C: Moderate degeneration—a great number of neurons in the gyrus are degenerated (HE, ×100). D: Severe degeneration—almost complete degeneration is present in dentate gyrus (HE, ×200). Surgical Neurology 2008 70, 344-351DOI: (10.1016/j.surneu.2007.07.052) Copyright © 2008 Elsevier Inc. Terms and Conditions