Anesthes. 2012;116(4): doi: /ALN.0b013e31824b9512 Figure Legend:

Slides:

Advertisements

Similar presentations

Date of download: 6/3/2016 Copyright © American College of Chest Physicians. All rights reserved. Tissue Factor, Thrombin, and Cancer * Chest. 2003;124(3_suppl):58S-68S.

Advertisements

From: Equipment-related Electrocardiographic Artifacts:Causes, Characteristics, Consequences, and Correction Anesthes. 2008;108(1): doi: /01.anes

Anesthes. 2008;108(3): doi: /ALN.0b013e Figure Legend:

From: Anesthetic Technique for Radical Prostatectomy Surgery Affects Cancer Recurrence:A Retrospective Analysis Anesthes. 2008;109(2): doi: /ALN.0b013e31817f5b73.

From: Breakdown of within- and between-network Resting State Functional Magnetic Resonance Imaging Connectivity during Propofol-induced Loss of Consciousness.

From: General Anesthetic-induced Seizures Can Be Explained by a Mean-field Model of Cortical Dynamics Anesthes. 2006;104(3): Figure Legend: Fig.

From: Myeloperoxidase-associated Tyrosine Nitration after Intratracheal Administration of Lipopolysaccharide in Rats Anesthes. 2002;97(4): Figure.

Figure Legend: Inhibition of Neuronal Apoptosis

Anesthes. 2013;118(6): doi: /ALN.0b013e318289bcba Figure Legend:

From: Transient Hyperglycemia Affects the Extent of Ischemia-Reperfusion-induced Renal Injury in Rats Anesthes. 2008;108(3): doi: /ALN.0b013e318164cff8.

From: Neurotoxicity of Lidocaine Involves Specific Activation of the p38 Mitogen-activated Protein Kinase, but Not Extracellular Signal–regulated or c-jun.

From: Gadgeteering for Health Care:The John W

From: Mechanisms of Direct Inhibitory Action of Propofol on Uterine Smooth Muscle Contraction in Pregnant Rats Anesthes. 2001;95(5): Figure Legend:

From: Assessment of the Accuracy of Procalcitonin to Diagnose Postoperative Infection after Cardiac Surgery Anesthes. 2007;107(2): doi: /01.anes ad.

Anesthes. 2004;100(4): Figure Legend:

From: Mechanical Function of the Left Atrium:New Insights Based on Analysis of Pressure–Volume Relations and Doppler Echocardiography Anesthes. 2003;98(4):

From: General Anesthetics Modify the Kinetics of Nicotinic Acetylcholine Receptor Desensitization at Clinically Relevant Concentrations Anesthes. 1995;82(1):

From: Molecular Mechanisms Transducing the Anesthetic, Analgesic, and Organ-protective Actions of Xenon Anesthes. 2006;105(1): Figure Legend: Fig.

Anesthes. 1998;88(6): Figure Legend:

Anesthes. 2010;113(4): doi: /ALN.0b013e3181ef6757 Figure Legend:

Anesthes. 2009;110(1): doi: /ALN.0b013e318190bc84 Figure Legend:

From: Perineural Administration of Dexmedetomidine in Combination with Bupivacaine Enhances Sensory and Motor Blockade in Sciatic Nerve Block without Inducing.

From: Overexpression of the μ-Opioid Receptor in Human Non-Small Cell Lung Cancer Promotes Akt and mTOR Activation, Tumor Growth, and Metastasis Anesthes.

Trans. Vis. Sci. Tech ;5(2):10. doi: /tvst Figure Legend:

From: Neurodevelopmental Assessment in Kindergarten in Children Exposed to General Anesthesia before the Age of 4 Years:A Retrospective Matched Cohort.

From: Negative Pressure Ventilation and Positive Pressure Ventilation Promote Comparable Levels of Ventilator-induced Diaphragmatic Dysfunction in Rats.

From: Protective Mechanical Ventilation during General Anesthesia for Open Abdominal Surgery Improves Postoperative Pulmonary Function Anesthes. 2013;118(6):

Anesthes. 2010;112(3): doi: /ALN.0b013e3181cea398 Figure Legend:

From: Influence of Methylenetetrahydrofolate Reductase Gene Polymorphisms on Homocysteine Concentrations after Nitrous Oxide Anesthesia Anesthes. 2008;109(1):36-43.

From: Coronary Artery Plaque Burden and Perioperative Cardiac Risk

Anesthes. 1997;87(3): Figure Legend:

From: Using Process Analysis to Assess the Impact of Medical Education on the Delivery of Pain Services:A Natural Experiment Anesthes. 2012;116(4):

From: Return-to-duty Rates among Coalition Forces Treated in a Forward-deployed Pain Treatment Center:A Prospective Observational Study Anesthes. 2007;107(6):

From: Evolution of the Inflammatory and Fibroproliferative Responses during Resolution and Repair after Ventilator-induced Lung Injury in the Rat Anesthes.

From: A Rational Approach to Perioperative Fluid Management

From: Physiologic and Antinociceptive Effects of Intrathecal Resiniferatoxin in a Canine Bone Cancer Model Anesthes. 2005;103(5): Figure Legend:

From: Propofol Attenuates Peroxynitrite-mediated DNA Damage and Apoptosis in Cultured Astrocytes:An Alternative Protective Mechanism Anesthes. 2004;101(6):

From: Isoflurane Modulation of Neuronal Nicotinic Acetylcholine Receptors Expressed in Human Embryonic Kidney Cells Anesthes. 2005;102(1): Figure.

From: Permanent Loss of Cervical Spinal Cord Function Associated with Interscalene Block Performed under General Anesthesia Anesthes. 2000;93(6):

From: Neurokinin-1 Receptor Antagonists Inhibit the Recruitment of Opioid-containing Leukocytes and Impair Peripheral Antinociception Anesthes. 2007;107(6):

Figure Legend: From: Does Size Matter?

Anesthes. 2000;92(4):931. Figure Legend:

(+)-Ketamine Suppresses Desensitization of γ-Aminobutyric Acid Type B Receptor-mediated Signaling by Inhibition of the Interaction of γ-Aminobutyric Acid.

From: Sites Related to Crawford Williamson Long in Georgia

From: Combined Thoracic Ultrasound Assessment during a Successful Weaning Trial Predicts Postextubation Distress Anesthes. 2017;127(4): doi: /ALN

Anesthes. 2009;110(1): doi: /ALN.0b013e318190b6a7 Figure Legend:

Anesthes. 2008;109(2):355. doi: /ALN.0b013e31817fb3f2 Figure Legend:

From: Volatile Anesthetics Reduce Invasion of Colorectal Cancer Cells through Down-regulation of Matrix Metalloproteinase-9 Anesthes. 2012;117(2):

From: A Simulation Study of Common Propofol and Propofol-Opioid Dosing Regimens for Upper Endoscopy:Implications on the Time Course of Recovery Anesthes.

Molecular targeted therapies in hepatocellular carcinoma: From pre-clinical models to clinical trials Pippa Newell, Augusto Villanueva, Josep M. Llovet

Overgrowth Syndromes Caused by Somatic Variants in the Phosphatidylinositol 3- Kinase/AKT/Mammalian Target of Rapamycin Pathway Gozde Akgumus, Fengqi.

Volume 56, Issue 3, Pages (March 2012)

A Flt3L Encounter: mTOR Signaling in Dendritic Cells

Macrophage Metabolism Shapes Angiogenesis in Tumors

Personalizing Therapy for Colorectal Cancer

Development of PI3K/AKT/mTOR Pathway Inhibitors and Their Application in Personalized Therapy for Non–Small-Cell Lung Cancer Vassiliki Papadimitrakopoulou,

Inhibition of mammalian target of rapamycin: Two goals with one shot?

Opioids and neovascularization; pro or anti?

Vascular Endothelial Growth Factor (VEGF) Pathway

FGFR Signaling as a Target for Lung Cancer Therapy

Nat. Rev. Nephrol. doi: /nrneph

Targeting STAT3 in hepatocellular carcinoma: Sorafenib again…

Vascular Endothelial Growth Factor and Epidermal Growth Factor Signaling Pathways as Therapeutic Targets for Colorectal Cancer Thomas Winder, Heinz–Josef.

SRC and STAT Pathways Journal of Thoracic Oncology

MicroRNA as Therapeutic Targets for Chronic Wound Healing

The new kid on the block(ade) of the IGF-1 receptor

Update on the Medical Treatment of Metastatic Renal Cell Carcinoma

Connections between insulin/insulin-like growth factor 1 signaling and metabolic pathways in tumor cells. Connections between insulin/insulin-like growth.

Cyclooxygenase (COX) independent chemopreventive mechanisms of non-steroidal anti-inflammatory drugs (NSAIDs). *Genes with a T cell factor 4 responsive.

A schematic diagram showing the mechanism by which L5 triggers platelet activation and aggregation. A schematic diagram showing the mechanism by which.

Presentation transcript:

From: The μ-Opioid Receptor in Cancer Progression:Is There a Direct Effect? Anesthes. 2012;116(4):940-945. doi:10.1097/ALN.0b013e31824b9512 Figure Legend: Fig. 1. Schematic diagram representing the mechanism(s) by which methylnaltrexone inhibits angiogenesis. Vascular endothelial growth factor (VEGF) binding to VEGF receptors induces Src activation, Src-mediated Akt, RhoA, and mammalian target of rapamycin (mTOR) activation and consequent endothelial cell proliferation, migration, and actin cytoskeletal reorganization required for angiogenesis. Methylnaltrexone (MNTX) inhibits the μ-opioid receptor (MOR) and promotes tyrosine phosphatase activity, leading to Src inactivation. This promotes Akt, RhoA, and mTOR inactivation and consequent inhibition of angiogenesis. Date of download: 10/16/2017 Copyright © 2017 American Society of Anesthesiologists. All rights reserved.