Relative Changes in Cerebral Blood Flow During Cardiac Operations Using Xenon-133 Clearance Versus Transcranial Doppler Sonography Uday H Trivedi, FRCS,

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Presentation transcript:

Relative Changes in Cerebral Blood Flow During Cardiac Operations Using Xenon-133 Clearance Versus Transcranial Doppler Sonography Uday H Trivedi, FRCS, Ramesh L Patel, FRCS(Ed), Mark R.J Turtle, PGDip, Graham E Venn, FRCS, David J Chambers, PhD The Annals of Thoracic Surgery Volume 63, Issue 1, Pages 167-174 (January 1997) DOI: 10.1016/S0003-4975(96)01017-X

Fig. 1 Changes in absolute values of cerebral blood flow (CBF) and cerebral blood flow velocity (VMCA) at the four phases of operation in patients subjected to (A) pH-stat and (B) alpha-stat acid-base management protocols. Dotted lines represent CBF; solid lines represent VMCA. Values are mean ± standard error of the mean. (CPB = cardiopulmonary bypass.) The Annals of Thoracic Surgery 1997 63, 167-174DOI: (10.1016/S0003-4975(96)01017-X)

Fig. 2 Relative changes in cerebral blood flow (CBF) and cerebral blood flow velocity (VMCA), expressed as the percentage of the prebypass value, which has been normalized to 100%, at 28°C bypass, at 37°C bypass, and after cardiopulmonary bypass (CPB) in patients subjected to (A) pH-stat and (B) alpha-stat acid-base management protocols. Dotted lines represent CBF; solid lines represent VMCA. Values are mean ± standard error of the mean. The Annals of Thoracic Surgery 1997 63, 167-174DOI: (10.1016/S0003-4975(96)01017-X)

Fig. 3 Correlation between absolute values of cerebral blood flow (CBF) and cerebral blood flow velocity (VMCA) for both the pH-stat group of patients (open circles) and the alpha-stat group of patients (closed squares) at the four phases of operation. The solid line represents the regression line for the pH-stat patients, with the coefficient of correlation (r) being 0.59 and the coefficient of determination (r2) being 0.35. The dotted line represents the regression line for the alpha-stat patients, with r = 0.59 and r2 = 0.35. The regression for all patients as a whole group (not shown) has an r of 0.60 and r2 of 0.36. The Annals of Thoracic Surgery 1997 63, 167-174DOI: (10.1016/S0003-4975(96)01017-X)

Fig. 4 Correlation between relative changes in cerebral flood flow (CBF) and cerebral blood flow velocity (VMCA) for both the pH-stat group of patients (open circles) and the alpha-stat group of patients (closed squares) at the 28°C bypass, 37°C bypass, and postbypass phases of operation (values are expressed as percentage of the prebypass value, normalized to 100%). The solid line represents the regression line for the pH-stat patients, with the coefficient of correlation (r) being 0.84 and the coefficient of determination (r2) being 0.70. The dotted line represents the regression line for the alpha-stat patients, with r = 0.90 and r2 = 0.80. The regression for all patients as a whole group (not shown) has an r of 0.89 and r2 of 0.79. The Annals of Thoracic Surgery 1997 63, 167-174DOI: (10.1016/S0003-4975(96)01017-X)