Volume 102, Issue 12, Pages (December 2008)

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Volume 102, Issue 12, Pages 1753-1761 (December 2008) HRCT and histopathological evaluation of fibrosis and tissue destruction in IPF associated with pulmonary emphysema Paola Rogliani, Marco Mura, Paolo Mattia, Amedeo Ferlosio, Gianfranco Farinelli, Salvatore Mariotta, Paolo Graziano, Gabriella Pezzuto, Alberto Ricci, Cesare Saltini, Augusto Orlandi Respiratory Medicine Volume 102, Issue 12, Pages 1753-1761 (December 2008) DOI: 10.1016/j.rmed.2008.07.010 Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 1 (A) Haematoxylin–Eosin stained section of an emphysema/UIP patient's lung parenchyma, showing emphysematous areas adjacent to regions more closely resembling classic UIP at low magnification. (B) Masson's trichrome stain of a classic fibroblastic focus in fibrotic area of emphysema/UIP lung parenchyma fibrotic area. Original magnifications, A=×20, B=×250. Respiratory Medicine 2008 102, 1753-1761DOI: (10.1016/j.rmed.2008.07.010) Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 2 Typical HRCT scan of an emphysema/UIP patient. (A) Fibrotic reticular lesions, prevalently subpleural, and extended emphysema, are seen in the upper fields. (C) Carena: coarse reticular lesions with subpleural cysts, predominantly in the left lung, and bullous emphysema at the apex of the inferior lobe and in the lingula. (E) Lower fields: coarse reticular lesions with subpleural and intraparenchymal cysts are seen bilaterally. Distribution of fibrosis visual scores in the upper (B), medium (D) and lower (F) fields in emphysema/UIP and UIP alone patients, respectively. Respiratory Medicine 2008 102, 1753-1761DOI: (10.1016/j.rmed.2008.07.010) Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 3 Immunohistochemical and semiquantitative analyses of matrix metalloproteinases (MMPs) expression in lung parenchyma interstitial fibroblasts (A–F). Immunohistochemical investigation of lung parenchymal interstitial MT1-MMP (A, B) MMP-9 (C, D) and MMP-7 (E, F) in emphysema/UIP (A,C,E) and typical emphysema (B,D,F). (G) Bar graph showing semiquantitative analysis that reveals interstitial fibroblasts of parenchymal destruction areas of emphysema/UIP stain more than in those of typical emphysema subjects. (H) Bar graph of semiquantitative evaluation of MMPs expression in fibroblast foci of lung parenchyma emphysema/UIP and UIP alone. Diaminobenzidine as chromogen; original magnification, ×200. Respiratory Medicine 2008 102, 1753-1761DOI: (10.1016/j.rmed.2008.07.010) Copyright © 2008 Elsevier Ltd Terms and Conditions