Histamine is correlated with liver fibrosis in biliary atresia

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Histamine is correlated with liver fibrosis in biliary atresia Kejun Zhou, Guoxiang Xie, Jie Wen, Jun Wang, Weihua Pan, Ying Zhou, Yongtao Xiao, Yang Wang, Wei Jia, Wei Cai  Digestive and Liver Disease  Volume 48, Issue 8, Pages 921-926 (August 2016) DOI: 10.1016/j.dld.2016.05.001 Copyright © 2016 Editrice Gastroenterologica Italiana S.r.l. Terms and Conditions

Fig. 1 OPLS-DA score plots of amino acid and biogenic amine profiles derived from UPLC-MS/MS from BA, NHS, and control infants. (A) OPLS-DA score plots between BA and control infants. (B) OPLS-DA score plots between NHS and control infants. (C) OPLS-DA score plots between BA and NHS infants. (D) OPLS-DA score plots between fibrosis stages 1–2 (F1-2) and 4 (F4) in BA infants. Digestive and Liver Disease 2016 48, 921-926DOI: (10.1016/j.dld.2016.05.001) Copyright © 2016 Editrice Gastroenterologica Italiana S.r.l. Terms and Conditions

Fig. 2 Relative histamine levels. (A) Relative histamine levels in the livers of BA, NHS, and control infants. (B) Relative histamine levels in the livers of different fibrosis stages of BA infants. *p<0.05; ***p<0.001. Digestive and Liver Disease 2016 48, 921-926DOI: (10.1016/j.dld.2016.05.001) Copyright © 2016 Editrice Gastroenterologica Italiana S.r.l. Terms and Conditions

Fig. 3 Expression of HDC and MAOB. (A) IHC of HDC in a BA liver. (B) IHC of MAOB in a BA liver. (C) Western blot of HDC and MAOB in livers of BA infants with fibrosis stages F1-2 and F4. *p<0.05. Digestive and Liver Disease 2016 48, 921-926DOI: (10.1016/j.dld.2016.05.001) Copyright © 2016 Editrice Gastroenterologica Italiana S.r.l. Terms and Conditions

Fig. 4 IHC of H1HR, H2HR, H3HR, and H4HR in BA livers. H1HR is expressed in the cholangiocytes of BA livers (arrows). Digestive and Liver Disease 2016 48, 921-926DOI: (10.1016/j.dld.2016.05.001) Copyright © 2016 Editrice Gastroenterologica Italiana S.r.l. Terms and Conditions