From: Experimental Anterior Ischemic Optic Neuropathy in Diabetic Mice Exhibited Severe Retinal Swelling Associated With VEGF Elevation Invest. Ophthalmol.

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Presentation transcript:

From: Experimental Anterior Ischemic Optic Neuropathy in Diabetic Mice Exhibited Severe Retinal Swelling Associated With VEGF Elevation Invest. Ophthalmol. Vis. Sci.. 2017;58(4):2296-2305. doi:10.1167/iovs.16-20308 Figure Legend: One day after AION, retinal and serum VEGF levels were significantly increased in DM-AION eyes, and treatment with insulin significantly reduced VEGF levels and retinal swelling on OCT. (A) Day 1 retinal VEGF levels in Ctrl and AION eyes in non-DM mice, DM mice without insulin treatment, and DM mice with insulin treatment. *P < 0.05. (B) Day 1 serum VEGF levels in non-DM mice with AION, DM mice with AION untreated with insulin, and DM mice with AION treated with insulin. *P < 0.05. (C) Bar graph showing relative increase in GCC (open bars) and total retinal thickness measurements (filled bars) one day after AION compared with baseline in DM-AION eyes without insulin treatment and in DM-AION eyes with insulin treatment. *P < 0.05. (D) Correlation between retinal VEGF levels and GCC (top) and total retinal thickness measurements (bottom) 1 day after AION (GCC: r = 0.818, P < 0.001, n = 25; total retinal thickness: r = 0.608, P = 0.001, n = 25). Date of download: 10/16/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.