Westerweel PE et al. Eur Heart J 2008;29:

Slides:

Advertisements

Similar presentations

SHARP trial Study of Heart and Renal Protection : a randomised placebo-controlled trial The e ﬀ ects of lowering LDL cholesterol with simvastatin plus.

Advertisements

Stents Are Not Enough: Statins Keith Channon Department of Cardiovascular Medicine University of Oxford John Radcliffe Hospital, Oxford.

The concept of Diabetes & CV risk: A lifetime risk challenge Vascular function as an early sign of trouble: How can the inhibition of cholesterol absorption.

Background  Hypertrigliceridaemia is common in patients with HIV, especially those taking protease inhibitors (PIs) or with lipodystrophy.  Although,

1 Doctors. 2 Information Needs Keeping up to date on research Continuing education.

Effects of Low-Fat Dairy Consumption on Markers of Low- Grade Systemic Inflammation and Endothelial Function in Overweight and Obese Subjects: An Intervention.

The Science of Plant Stanol Ester. Contents Background Plant stanol ester and LDL-cholesterol lowering Dose-response of plant stanol ester with high daily.

Role of Rosuvastatin in the Treatment of Dyslipidemia

Management of Dyslipidemia in Patients with Peripheral Arterial Disease: an update from Guidelines Oman International Vascular Conference Al-Bustan Palace.

HYPERLIPIDAEMIA. 4S 4444 patients –Hx angina or MI –Cholesterol Simvastatin 20mg (10-40) vs. placebo FU 5 years  total cholesterol 25%;  LDL.

THE EFFECTS OF INTERMITTENT VITAMIN D3 SUPPLEMENTATION ON MUSCLE STRENGHT AND METABOLIC PARAMETERS IN POSTMENOPAUSAL WOMEN WITH TYPE 2 BIABETES: A RANDOMIZED.

Philip J. Barter, et al. Circulation 2011;124:

Copyright® Raisio A plant stanol yogurt drink alone or combined with a low-dose statin lowers serum triacylglycerol and non-HDL cholesterol.

Endothelial Progenitor Cells (EPCs)

Copyright® Raisio Effects of long-term plant sterol or stanol ester consumption on lipid and lipoprotein metabolism in subjects on statin treatment.

Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 2 ARBITER-2 Trial Presented at The American Heart Association Scientific.

Clinical Trial Results. org Anti-Inflammatory Effects of Pioglitazone and/or Simvastatin in High Cardiovascular Risk Patients With Elevated High Sensitivity.

Yunoki K et al. Atherosclerosis 2011 Epub Apr 22.

Copyright® Raisio Reduction of serum cholesterol in postmenopausal women with previous myocardial infarction and cholesterol malabsorption induced.

Baseline Patient Characteristics Bart A.N. Verhoeven, et al. Stroke 2006;37:

4S: Scandinavian Simvastatin Survival Study

Characteristics of Patients With CHF Ulf Landmesser et al Circ. 2005; 111:

Study Flow Diagram Holvoet P, et al. JAMA 2008;299: The Figure shows the selection of 1889 participants who did not have metabolic syndrome at year.

Trial profile Prakash Deedwania, et al. Lancet 2006; 368:

Cholesterol-lowering effects of a stanol- ester containing low-fat margarine used in conjunction with a strict lipid-lowering diet Andersson A et al. Eur.

Plant stanol esters in human studies Professor Helena Gylling University of Kuopio.

Effect of fish oil supplementation on serum triglycerides, LDL cholesterol and LDL subfractions in hypertriglyceridemic adults B. Oelrich, A. Dewell,

GLYPICAN-4 LEVELS IN RELATION WITH HORMONAL AND METABOLIC PROFILE IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME Doç.Dr.Özlem ALTINKAYA.

Deﬁnitions of the MetS by the WHO, EGIR, NCEP, ACE, IDF, and updated NCEP criteria Wang J, et al. Eur Heart J 2007;28:

Net metabolic rate of walking at 1. 5 m/s vs

Do PCSK9 Inhibitors Cause Cognitive Impairment?

Vascular Trauma Induces Rapid but Transient Mobilization of VEGFR2+AC133+ Endothelial Precursor Cells by Muhammad Gill, Sergio Dias, Koichi Hattori, Mary.

FATS- Familial Atherosclerosis Treatment Study

Effects of High Density Lipoprotein Raising Therapies on Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus, with or without Renal Impairment:

Cholesterol and blood pressure values at baseline and after 15 days of dark-chocolate and white-chocolate consumption Characteristic Dark chocolate before.

The following slides highlight a report on a presentation at the Canadian Cardiovascular Congress held in Toronto, Ontario from October 24 to 29, 2003.

by Petri Salven, Lasse Teerenhovi, and Heikki Joensuu

LDL-C Goals. The Patient With Difficult-to-Treat Hypercholesterolemia: Is Everything Under Control?

Section 7: Aggressive vs moderate approach to lipid lowering

Hajer GR et al. Atherosclerosis 2009;202:216-24

Comparison of NRTI combinations

Sudhop T. et al. J Lipid Res 2009 Apr 20 [Epub ahead of print]

Comparison of the bronchoalveolar lavage fluid (BALF) levels of the three vascular endothelial growth factor (VEGF) types in healthy volunteers and patients.

Heart Protection Study Collaborative Group Lancet 2011;377:469-76

Flow Diagram of the Trial Selection Process

Baseline Characteristics, Blood Pressures, and Laboratory Values

Baseline Characteristics of the Subjects*

Baseline Demographic Characteristics of Adults With Diagnosed Heart Failure and Eligible to Receive Lipid-Lowering Therapy Alan S. Go, et al.

Tremblay AJ. Et al. J Lipid Res 2009 Mar 22 [Epub ahead of print]

Disposition of Patients in the Atherogenic Dyslipidemia Study

Demographic and Clinical Characteristics (means ± SD or %) of Subjects in Different Office SBP and DBP Categories Mancia G et al Hypertension. 2005;45:1072.

Comparison of the serum levels of the three vascular endothelial growth factor (VEGF) types in healthy volunteers and patients with idiopathic pulmonary.

Baseline Characteristics of the Patients – Part I

Circulating Endothelial Progenitor Cells Are Increased in Patients with Classic Kaposi's Sarcoma Adriano Taddeo, Pietro Presicce, Lucia Brambilla, Monica.

Figure 2 Peripheral blood lymphocyte subset counts during dimethyl fumarate treatment(A) Lymphocyte subsets were obtained at baseline (n = 21) and at month.

RADIANCE 2 Study: Trial proﬁle

(A) Absolute and (B) change from baseline in 6 min walk distance over time for all patients and by Down syndrome status. (A) Absolute and (B) change from.

Titration activities from baseline up to 6 and 12 months follow-up in nurse-coordinated care (NCC) versus usual care patients. X-as: patients (percentage),

Post-ischemic vascular repair mechanisms and the growth factors involved. Post-ischemic vascular repair mechanisms and the growth factors involved. The.

(A) Absolute and B) change from baseline in 6 min walk distance over time for patients on bosentan monotherapy by Down syndrome status. (A) Absolute and.

Relationship between selected metabolic parameters and the primary composite end point. Relationship between selected metabolic parameters and the primary.

Baseline Clinical Characteristics of All Patients and Patients Grouped by Statin Therapy - Part I H. Fukuta et al. Circulation 2005;112:

A and B: Flow cytometric analysis of the effect of MRP-8/14 in the serum of a type 1 diabetic patient on the surface expression of CD11b and CD118. A and.

Flow of study participants

DPP4 release of explants obtained from adipose tissue of lean controls and obese patients before and after bariatric surgery, and linear correlation with.

Metabolic parameters in the three groups of patients during l-arginine infusion. Metabolic parameters in the three groups of patients during l-arginine.

Percentage change from baseline in homeostatic model assessment (HOMA) score, vascular endothelial growth factor (VEGF), epidermal growth factor (EGF),

Empty basement membrane sleeves and endothelial sprouts.

Effect of aspirin (ASA) on serum cytokine concentration in hemodialysis (HD) patients. Effect of aspirin (ASA) on serum cytokine concentration in hemodialysis.

Medication intensity (ALLP) changes between baseline and 6 months, by (not) being low-density lipoprotein-cholesterol (LDL-C) target at baseline for nurse-coordinated.

Presentation transcript:

Westerweel PE et al. Eur Heart J 2008;29:2808-17

Patient flow diagram Westerweel PE et al. Eur Heart J 2008;29:2808-17

Baseline subject characteristics and effect of treatment on general parameters Westerweel PE et al. Eur Heart J 2008;29:2808-17

Endothelial progenitor cell (EPC) levels are reduced in subjects with the metabolic syndrome Endothelial progenitor cell (EPC) levels are reduced in subjects with the metabolic syndrome. Both lipid-lowering treatments increased EPC levels. Circulating levels of CD34þKDRþ EPCs quantified per mL blood were reduced in obese men with the metabolic syndrome (MetS) when compared to matched controls. Combination treatment of 10 mg simvastatin with 10 mg ezetimibe lowered LDL-cholesterol similarly as monotherapy with 80 mg simvastatin. There were no significant differences between the two treatment arms. Mean+SD cells/ mL. *P < 0.05. Westerweel PE et al. Eur Heart J 2008;29:2808-17

Regression analysis for endothelial progenitor cell levels in healthy controls and obese men with the metabolic syndrome at baseline combined Westerweel PE et al. Eur Heart J 2008;29:2808-17

Regression analysis of progenitor cell mobilizing cytokines with progenitor cell levels Westerweel PE et al. Eur Heart J 2008;29:2808-17

Serum levels of progenitor cell mobilizing cytokines vascular endothelial growth factor (VEGF) and SCF-sR before and after treatment Serum levels of progenitor cell mobilizing cytokines vascular endothelial growth factor (VEGF) and SCF-sR before and after treatment. At baseline, serum VEGF levels were lower in subjects with the metabolic syndrome, although this was not statistically significant (A). After both lipid-lowering treatment regimens, VEGF levels further decreased (A). Serum SCF-sR levels were significantly reduced in subjects with the metabolic syndrome at baseline compared to controls and increased to control levels after both treatment regimens (B). Mean+SD pg or ng/mL. *P < 0.05 vs. controls. #P < 0.05 vs. baseline. Westerweel PE et al. Eur Heart J 2008;29:2808-17