Does statin therapy reduce plasma VEGF levels in humans

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Does statin therapy reduce plasma VEGF levels in humans Does statin therapy reduce plasma VEGF levels in humans? A systematic review and meta-analysis of randomized controlled trials Amirhossein Sahebkar, Maria Chantal Ponziani, Ilaria Goitre, Simona Bo Metabolism - Clinical and Experimental Volume 64, Issue 11, Pages 1466-1476 (November 2015) DOI: 10.1016/j.metabol.2015.08.002 Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 1 Flow chart of the number of studies identified and included into the meta-analysis. Metabolism - Clinical and Experimental 2015 64, 1466-1476DOI: (10.1016/j.metabol.2015.08.002) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 2 Forest plot displaying weighted mean difference and 95% confidence intervals for the impact of statin therapy on plasma VEGF concentrations. Lower plot shows leave-one-out sensitivity analysis. Metabolism - Clinical and Experimental 2015 64, 1466-1476DOI: (10.1016/j.metabol.2015.08.002) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 3 Meta-regression plots of the association between mean changes in plasma VEGF concentrations with duration of statin therapy, magnitude of LDL-C reduction, and molar dose of statins. Metabolism - Clinical and Experimental 2015 64, 1466-1476DOI: (10.1016/j.metabol.2015.08.002) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 4 Funnel plot displaying publication bias in the studies reporting the impact of statin therapy on plasma VEGF concentrations. Open diamond represents observed effect size; closed diamond represents imputed effect size. Metabolism - Clinical and Experimental 2015 64, 1466-1476DOI: (10.1016/j.metabol.2015.08.002) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 1S Forest plot displaying weighted mean difference and 95% confidence intervals for the impact of statin therapy on plasma VEGF concentrations in trials with treatment durations of <4weeks (upper plot) and ≥4weeks (lower plot). Metabolism - Clinical and Experimental 2015 64, 1466-1476DOI: (10.1016/j.metabol.2015.08.002) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 2S Forest plot displaying weighted mean difference and 95% confidence intervals for the impact of statin therapy on plasma VEGF concentrations in trials with LDL-cholesterol reductions <50mg/dL (upper plot) and ≥50mg/dL (lower plot). Metabolism - Clinical and Experimental 2015 64, 1466-1476DOI: (10.1016/j.metabol.2015.08.002) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 3S Forest plot displaying weighted mean difference and 95% confidence intervals for the impact of statin therapy on plasma VEGF concentrations in trials with lipophilic (upper plot) and hydrophilic statins (lower plot). Metabolism - Clinical and Experimental 2015 64, 1466-1476DOI: (10.1016/j.metabol.2015.08.002) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 4S Forest plot displaying weighted mean difference and 95% confidence intervals for the impact of statin therapy on plasma VEGF concentrations in trials with diseased (upper plot) and healthy populations (lower plot). Metabolism - Clinical and Experimental 2015 64, 1466-1476DOI: (10.1016/j.metabol.2015.08.002) Copyright © 2015 Elsevier Inc. Terms and Conditions