Figure 1 Flow diagram displaying the proportions of patients with troponin measurements available from all eligible patients and the resulting study population.

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Figure 1 Flow diagram displaying the proportions of patients with troponin measurements available from all eligible patients and the resulting study population with simultaneously all four troponin measurements available. From: Risk stratification in patients with acute chest pain using three high-sensitivity cardiac troponin assays Eur Heart J. 2013;35(6):365-375. doi:10.1093/eurheartj/eht218 Eur Heart J | Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2013. For permissions please email: journals.permissions@oup.com

Figure 2 (A and B) Presentation values of high-sensitivity cardiac troponins and cardiac troponin T in survivors and non-survivors during the first (A) 30 days and (B) 730 days; all values are displayed in nanogram per litre and as median values with inter-quartile ranges and outliers. From: Risk stratification in patients with acute chest pain using three high-sensitivity cardiac troponin assays Eur Heart J. 2013;35(6):365-375. doi:10.1093/eurheartj/eht218 Eur Heart J | Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2013. For permissions please email: journals.permissions@oup.com

Figure 3 (A and B) Area under the receivers operating characteristic curve displaying prognostic accuracy of high-sensitivity cardiac troponin assays for (A) early (30 days) and (B) long-term (730 days) all-cause mortality in comparison with cTnT4 (Roche Diagnostics). (C) Kaplan–Meier curves displaying cumulative survival during the follow-up in all acute chest pain patients stratified by presentation values of high-sensitivity cardiac troponin above (+) and below (−) the respective 99th percentile. (D and E) Area under the receivers operating characteristic curve displaying prognostic accuracy for long-term (730 days) all-cause mortality of high-sensitivity cardiac troponin assays for patients without (D) and with (E) acute myocardial infarction at presentation in comparison with cTnT4 (Roche Diagnostics); the area under the receivers operating characteristic curve of high-sensitivity cardiac Troponin T (Roche Diagnostics) was significantly higher than for both hs-cTnI assays in both patients with and without acute myocardial infarction at presentation; the area under the receivers operating characteristic curve for both hs-cTnI assays in patients with acute myocardial infarction did not reach statistical significance. Using either of the two hs-cTnI assays for the adjudication of acute myocardial infarction did not change the above results significantly. From: Risk stratification in patients with acute chest pain using three high-sensitivity cardiac troponin assays Eur Heart J. 2013;35(6):365-375. doi:10.1093/eurheartj/eht218 Eur Heart J | Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2013. For permissions please email: journals.permissions@oup.com

Figure 4 Serial median high-sensitivity cardiac Troponin T (Roche diagnostics) values in patients surviving and dying within 730 days. All values are displayed as median value (with inter-quartile range) in nanogram per litre. From: Risk stratification in patients with acute chest pain using three high-sensitivity cardiac troponin assays Eur Heart J. 2013;35(6):365-375. doi:10.1093/eurheartj/eht218 Eur Heart J | Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2013. For permissions please email: journals.permissions@oup.com

Figure 5 (A) Area under the receivers operating characteristic curve displaying prognostic accuracy of high-sensitivity cardiac Troponin T and its early changes within the first 6 h for long-term (730 days) all-cause mortality; (B) mortality rates at 730 days for patients subdivided in six groups according to presentation values of high-sensitivity cardiac Troponin T. From: Risk stratification in patients with acute chest pain using three high-sensitivity cardiac troponin assays Eur Heart J. 2013;35(6):365-375. doi:10.1093/eurheartj/eht218 Eur Heart J | Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2013. For permissions please email: journals.permissions@oup.com