Treatment of Cachexia With Ghrelin in Patients With COPD

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Presentation transcript:

Treatment of Cachexia With Ghrelin in Patients With COPD Nagaya Noritoshi , MD, Itoh Takefumi , MD, Murakami Shinsuke , MD, Oya Hideo , MD, Uematsu Masaaki , MD, Miyatake Kunio , MD, Kangawa Kenji , PhD CHEST Volume 128, Issue 3, Pages 1187-1193 (September 2005) DOI: 10.1378/chest.128.3.1187 Copyright © 2005 The American College of Chest Physicians Terms and Conditions

Figure 1 Changes in serum GH level after a single administration of ghrelin in patients with COPD. CHEST 2005 128, 1187-1193DOI: (10.1378/chest.128.3.1187) Copyright © 2005 The American College of Chest Physicians Terms and Conditions

Figure 2 Effects of a 3-week administration of ghrelin on food intake (left, A), body weight (middle, B), and lean body mass (right, C). CHEST 2005 128, 1187-1193DOI: (10.1378/chest.128.3.1187) Copyright © 2005 The American College of Chest Physicians Terms and Conditions

Figure 3 Changes in hand-grip strength (left, A), maximal inspiratory pressure (middle, B), and maximal expiratory pressure (right, C) before and after ghrelin therapy. CHEST 2005 128, 1187-1193DOI: (10.1378/chest.128.3.1187) Copyright © 2005 The American College of Chest Physicians Terms and Conditions

Figure 4 Changes in Karnofsky performance status score (left, A) and the distance walked in 6 min (right, B) before and after ghrelin therapy. CHEST 2005 128, 1187-1193DOI: (10.1378/chest.128.3.1187) Copyright © 2005 The American College of Chest Physicians Terms and Conditions

Figure 5 Plasma norepinephrine level before and after ghrelin therapy. CHEST 2005 128, 1187-1193DOI: (10.1378/chest.128.3.1187) Copyright © 2005 The American College of Chest Physicians Terms and Conditions