Synergistic effects of progranulin and low intensity pulsed ultrasound on chondrocyte differentiation, migration and metabolism S.M. Uddin, B. Richbourgh,

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Synergistic effects of progranulin and low intensity pulsed ultrasound on chondrocyte differentiation, migration and metabolism S.M. Uddin, B. Richbourgh, Y.-S. Yi, C. Liu Osteoarthritis and Cartilage Volume 23, Pages A144-A145 (April 2015) DOI: 10.1016/j.joca.2015.02.887 Copyright © 2015 Terms and Conditions

Fig 1A LIPUS enhances chondrogenesis and neutralizes IL-1beta B) LIPUS restores IL-1beta induced chondrocytes migration inhibition. Osteoarthritis and Cartilage 2015 23, A144-A145DOI: (10.1016/j.joca.2015.02.887) Copyright © 2015 Terms and Conditions

Figure 2. A)combine treatment of PGRN and LIPUS show synergistic effects in chondrocytes anabolism. B) LIPUS +PGRN treatment enhances saffron O staining and protect against cytokines induce cartilage degradation. Osteoarthritis and Cartilage 2015 23, A144-A145DOI: (10.1016/j.joca.2015.02.887) Copyright © 2015 Terms and Conditions

Figure 3. PGRN and LIPUS role in inhibition of inflammatory and activation of chondrogenic pathways. Osteoarthritis and Cartilage 2015 23, A144-A145DOI: (10.1016/j.joca.2015.02.887) Copyright © 2015 Terms and Conditions